Effects of Diffusion on Free Precession in Nuclear Magnetic Resonance Experiments in Physical Review 94, No. 3, May 1, 1954, pp. 630-638 [NMR]

FIRST EDITION IN ORIGINAL WRAPS OF A PIONEERING PAPER IN MAGNETIC RESONANCE IMAGING. Carr and Purcell "showed that a simple modification of Hahn's spin-echo method reduces drastically the effect of diffusion" in magnetic resonance, thus increasing its reliability (Aligizaki, 213). Otto Hahn recognized "the sensitivity of the spin echo MR signal on molecular diffusion. While he proposed that one could measure the diffusion coefficient of a solution containing spin-labeled molecules, he did not propose a direct method for doing so. [In 1954 in this paper], Carr and Purcell proposed a complete mathematical and physical framework for such a measurement using Hahn's NMR spin echo sequence. They realized that the echo magnitude could be sensitized solely to the effects of random molecular spreading caused by diffusion in a way that permits a direct measurement. "Carr and Purcell's proposed MR sequences sensitized the MR spin echo to the effects of diffusion" (Johansen-Berg, Diffusion MRI, 6). As a result, they were able to develop "a rigorous mathematical framework to measure the diffusion coefficient from such sequences. This elevated NMR to being a 'gold standard' for measuring molecular diffusion" (ibid). CONDITION & DETAILS: First edition in original wraps. Lancaster: American Physical Society. Very, very slight wear at the foot of the spine and at the edges of the wraps. Very good condition. …