Garrod's Inborn Factors in Disease. Including an annotated facsimile reprint of The Inborn Factors in Disease [1931].

GARROD, Archibald E. [Edward] (1857-1936); SCRIVNER, Charles R. [Robert] (1930-) & Barton CHILDS:

ISBN 10: 0192615742 / ISBN 13: 9780192615749

Published by Oxford, etc.: Oxford University Press, 1989., 1989

About this Item

1 leaf, xiv, 248 pp; portrait; figs. Original cloth. Near Fine, in near fine dust jacket. Oxford Monographs on Medical Genetics 16. Pp. 25-184 (160 pp in original edition) = Facsimile Reprint of Garrison-Morton 253.2 (1st ed., 1931): 'Garrod argued that chemical individuality could result in individuals having a predisposition to certain diseases. This view has become particularly significant in light of the establishment of recombinant DNA methods to identify inherited genetic defects. Reprint with epilogue by C.R. Scrivner and B. Childs, and bibliography of Garrod's writings, Oxford, Oxford University Press, 1989 [offered here].' Pp. v-viii = Foreword by Joshua Lederberg.

Seller Inventory # 18838

Bibliographic Details

• Title: Garrod's Inborn Factors in Disease. Including an annotated facsimile reprint of The Inborn Factors in Disease [1931].
• Publisher: Oxford, etc.: Oxford University Press, 1989.
• Publication Date: 1989
• Language: English
• ISBN 10: 0192615742
• ISBN 13: 9780192615749
• Binding: Hardcover
• Edition: 1st Edition
• Condition: Near Fine
• Dust Jacket Condition: Near Fine

About this title

Synopsis

Sir Archibald Garrod's first book, Inborn Errors of Metabolism (Oxford , 1908; reprint 1963), established chemical individuality as the paradigm of Mendelian variation. At the end of his career, Garrod wrote Inborn Factors in Disease (1931), in which he set out his belief that chemical individuality could result in individuals having a predisposition to certain diseases. It was not well received at the time, but now that many infectious diseases which have been the scourge of previous generations have been controlled, the relative importance of genetic disease has increased dramatically, while the establishment of recombinant DNA methods has made it possible to identify inherited defects and risks in the genes of individuals and families. How these individuals and their families can be helped is a major challenge for today's medicine and for society. Thus, it is timely to reprint Garrod's own words which anticipated that challenge so well. This facsimile reprint contains the entire original text, along with historical commentary and observations regarding Garrod's relevance today.