A Genetic Switch Phage (lambda) and Higher Organisms, Second Edition

Mark Ptashne

ISBN 10: 0865422095 / ISBN 13: 9780865422094

Published by Cell Press & Blackwell, Cambridge, Mass. 1992, 1992

About this Item

* Herausgeber ? : ? Blackwell Science Ltd; Subsequent Edition (1. Mai 1992) * Sprache ? : ? Englisch * Taschenbuch ? : ? 270 Seiten * ISBN-10 ? : ? 0865422095 * ISBN-13 ? : ? 978-0865422094 * Abmessungen ? : ? 17.15 x 1.27 x 23.5 cm The first edition of A GENETIC SWITCH, published in 1986 to worldwide acclaim, addressed one of the central questions in biology?how does an organism use its genes to direct its growth? The text drew on the author's 25 years of research on regulation in phage X, providing a paradigm of hoW cells select which genes to switch.off and on. In this second edition, Mark Ptashne refines what is known about X, and extends the treatment to consider gene regulation in higher organisms. Threc chapters describe the principles of gene regulation in X, and the fourth chapter outlines the experimental bases of the major conclusions. Two new chapters assess how far gene control in eukaryotes can he considered in terms of the X model, and what elaborations of the principles established with X are necessary to explain more complex programs of gene expression. Mark Ptashne is Ludwig Professor of Molecular Biology at the Sloan-Kettering Institute. From the reviews of the first edition \. TW work is a paradigm for the mechanisms of regulation. A clear exposition of a series of, triumphant experiments and insights that have brought us close to the molecular heart of the matter of genetic regulation. Sydney Brenner, Nature A marvelous new book. Ptashne provides a lucid and very logical progression through this maze of gene regulation. An excellent method to teach science. Anne Delle, New Scientist Succeeds in giving a complete and current account of the molecular interactions that govern the on and off states of the best known regulator of gene expression. Without omitting details, the book makes the sophisticated molecules seem simple and accessible to all. Serves as a springboard for the next generation. Naomi Franklin, The Scientist A concise description of the mechanism that has evolved to regulate the growth of bacteriophage X in its host, E. coli. That a bacterial virus has evolved such a switch is a fast ripe for appreciation by all scientists. Crisp, clear illustrations of science at its best. Steven McKnight, Science gutes Exemplar, ordentlich, * Verlag: Cell Press & Blackwell, Cambridge, Mass. 1992 * Bindung: broschiert,

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Bibliographic Details

• Title: A Genetic Switch Phage (lambda) and Higher Organisms, Second Edition
• Publisher: Cell Press & Blackwell, Cambridge, Mass. 1992
• Publication Date: 1992
• Language: English
• ISBN 10: 0865422095
• ISBN 13: 9780865422094
• Binding: Soft cover
• Edition: 1st Edition
• Weight: 400 grams

About this title

Synopsis

An extension of the 1986 edition to include higher organisms, focusing on how an organism uses its genes to direct its growth. New chapters assess how well the lambda model can explain gene control in eukaryotes, and the elaborations necessary to explain more complex systems. Annotation copyright Book News, Inc. Portland, Or.