Genome Mapping: A Practical Approach

Genome analysis has undergone a period of explosive growth in recent years. This book describes the most up-to-date methods for genome mapping, arranged in order of increasing resolution, from linkage analysis to restriction mapping. Topics covered include linkage mapping of human, animal, and plant genomes; mapping of quantitative trait loci; radiation hybrid mapping; HAPPY mapping; somatic cell hybrids; flow-sorted and microdissected chromosomes; fluorescence in situ hybridization; contig assembly; chromosome walking; and long-range restriction mapping. Two extensive appendices describe sources of freely available biological and computational resources relevant to genome analysis. Genome Mapping: A Practical Approach is a unique compendium and practical guide to the current technology. It will be of major interest to all researchers in academic and clinical genetics laboratories, including those concerned with animal and plant breeding programmes.

Dr Paul Dear, MRC Centre, Hills Road, Cambridge CB2 2QH. Email: phd@mrc-lmb.cam.ac.uk. Tel: 01223 402190. Fax: 01223 412178