Human Gene Evolution (Human Molecular Genetics)

Presents the principles of human gene evolution in a concise and easy to understand fashion. Uses examples of how evolutionary processes have molded present day genes, drawn from the evolution of humans and other primates, as well as from more primitive organisms. With increasing attention in this expanding area, this review forms a timely publication of our current knowledge of this important field.

• Structure and function in the human genome
• The evolution of gene structure
• Mutational mechanisms in evolution

The Human Genome Project is soon expected to yield the entire sequence of the human genome, providing an unparalleled opportunity to understand its structure, function and evolution. Human Gene Evolution bring together the highly dispersed literature on human gene structure, function, organization and expression, integrates this with our emerging knowledge of chromosome and genome structure, and discusses the nature of the mutational mechanisms that underlie evolutionary change.
A companion volume to the best-selling Human Gene Mutation by the same author, a central theme to this book is that mutations in human gene pathology and evolution represent two sides to the same coin, in that those same mutational mechanisms that have been frequently implicated in human pathology have also been involved in fashioning evolutionary change.
Human Gene Evolution is an authoritative and timely review of our current knowledge of this important field. It is essential reading for human molecular geneticists and for post-graduate students and interested clinicians.
"Professor Cooper has given us a comprehensive, authoritative, fascinating and masterful account of the evolutionary history of the human genes. Human Gene Evolution is recommended for the novice and the experienced alike." Professor Stylianos Antonarakis