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1962 signed and inscribed first edition, association copy (1977 Nobel winner Roger Guillemin), Akademiai Kiado (Budapest, Hungary), 7 x 9 5/8 inches tall blue cloth hardcover in publisher's unclipped dust jacket, gilt lettering to spine, copiously illustrated with black-and-white and color photographs and drawings, 330 pp. Laid in is a card reading, 'From the Private Collection of Dr. Roger and Lucienne Guillemin, Nobel Laureate, 1977, Salk Institute, La Jolla, CA.' Roger Charles Louis Guillemin was a French-American neuroscientist who received the National Medal of Science in 1976, and the Nobel Prize for Medicine in 1977 for his work on neurohormones. On the half title page, nicely signed by all four authors and inscribed to Guillemin, who made notations in red to the blank front free-endpaper and the front of the dust jacket. Slight soiling, rubbing and edgewear to covers, with mild bumping to tips. Front signature slightly pulled. Otherwise, a very good copy - clean, bright and unmarked - in a soiled, rubbed, edgeworn and edge-chipped dust jacket which is nicely preserved and displayed in a clear archival Brodart sleeve. ~SP42~ [3.0P] This well-illustrated monograph documents ten years of research on the interrelation of the hypothalamus and anterior pituitary by the Department of Anatomy of the Pecs University Medical School in Hungary. It includes a large store of new data as well as a critical and scholarly review of the literature. There is a detailed analysis of the anatomy of the region utilizing a wide variety of experimental techniques. The authors' extensive studies of the role of the hypothalamus in controlling the thyrotrophic, adrenotrophic and gonadotrophic functions of the pituitary are summarized. There is emphasis on feedback systems as servomechanisms regulating neuroendocrine functions. A number of new concepts are raised which required further study to establish their validity. The data describing the existence of neurosecretory mechanisms localized in the hypothalamus which effect anterior pituitary function via the portal circulation was of particular interest. About the prior owner: From the library of Roger Guillemin (1924-2024), a French-American neuroscientist, who joined the Salk Institute in 1970 at the invitation of Jonas Salk. In separate research laboratories, Guillemin and neuroscientist Andrew Schally (1926-2024) discovered the structures of Thyrotropin-releasing hormone (TRH) and Gonadotropin-releasing hormone (GnRH). They were jointly awarded the 1977 Nobel Prize in Physiology or Medicine for this discovery. In addition, Guillemin received awards from the National Academy of Sciences, 1974; the Canada Gairdner International Award, 1974; the Albert Lasker Award for Basic Medical Research, 1975; the Dickson Prize in Medicine, 1976; the Passano Award in Medical Sciences, 1976; the National Medal of Science, 1976; and from the American Academy of Arts and Sciences, 1977.
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