The Lymphatic System in Colorectal Cancer: Basic Concepts, Pathology, Imaging, and Treatment Perspectives

The Lymphatic System in Colorectal Cancer: Basic Concepts, Pathology, Imaging, and Treatment Perspectives provides an in-depth overview on the role of the lymphatic system in the pathogenesis and treatment of colorectal cancer. This is the first book to provide a comprehensive, multidisciplinary approach to the lymphatic system in colorectal cancer, with topics ranging from cancer biology and mathematical modeling to surgical approaches and novel imaging techniques. This book is valuable for cancer researchers, oncologists and anyone interested in the biology and treatment of colorectal cancer. Bringing together internationally renowned experts, the book's chapters encompass relevant content to help readers understand complex subjects.

Lymphatic spread is one of the hallmarks of locally advanced colorectal cancer that adversely affects prognosis. Nevertheless, the molecular pathogenesis, dynamics and prognostic significance of lymphatic spread remain poorly understood. At the same time, novel surgical approaches such as complete mesocolic excision and sentinel node identification are being introduced, but their value remains uncertain.

• Presents a multidisciplinary approach, allowing readers to identify relevant fields of collaboration and inspire novel research endeavors in the field
• Discusses novel imaging techniques such as near-infrared that is being introduced in clinical practice as a tool for identifying sentinel nodes and lymphatic pathways
• Brings together international experts who shed light on the most relevant aspects of lymphatic spread in cancer of the bowel, underlying mechanisms, and the best method to avoid or treat it

Wim P CEELEN, MD, PhD, FACS, is an academic surgical oncologist who is active in clinical, translational, and preclinical research. He has an active interest in the role and pathophysiology of lymph node metastasis in colorectal cancer and has published in this field intensively. Dr Ceelen has previously edited two volumes on peritoneal metastasis and intraperitoneal drug delivery. He has coauthored over 200 scientific publications to date.