The Machinery of Life

xii, 167, [5] pages. Illustrations (Color). Additional Reading. Index. David S. Goodsell, is an associate professor at the Scripps Research Institute and research professor at Rutgers University, New Jersey (joint appointment). He is especially known for his watercolor paintings of cell interiors. Since completing his Ph.D. he has worked as a structural biologist at the Scripps Research Institute (with a 2-year period in University of California in 1992-94). His research topics have included the use of structural biology and molecular dynamic simulations to investigate symmetry in protein oligomers, protein-protein interactions and for computer-aided drug design. In particular he is a developer of AutoDock, the most widely-used program used for molecular docking. His main research focus areas are HIV drug resistance and structure and function of bacterial cells. Goodsell has developed a signature style of scientific drawing. He started painting early in his childhood but did not study art in college. In graduate school, Goodsell became interested in scientific illustration while writing molecular graphics programs to visualize protein and DNA structures. Goodsell's signature style uses generally very flat shading, with strong and simple color-schemes. As is typical in medical illustration, the images are simplified representations of the subject that still retain accuracy of the important features. His illustrations fall broadly into two categories: individual proteins, and cellular panoramas. Imagine that we had some way to look directly at the molecules in a living organism. An x-ray microscope would do the trick, or since we're dreaming, perhaps an Asimov-style nanosubmarine (unfortunately, neither is currently feasible). Think of the wonders we could witness firsthand: antibodies attacking a virus, electrical signals racing down nerve fibers, proteins building new strands of DNA. Many of the questions puzzling the current cadre of scientists would be answered at a glance. But the nanoscale world of molecules is separated from our everyday world of experience by a daunting million-fold difference in size, so the world of molecules is completely invisible. He created the illustrations in this book to help bridge this gulf and allow us to see the molecular structure of cells, if not directly, then in an artistic rendition. He has included two types of illustrations with this goal in mind: watercolor paintings which magnify a small portion of a living cell by one million times, showing the arrangement of molecules inside, and computer-generated pictures, which show the atomic details of individual molecules. In this second edition of The Machinery of Life, these illustrations are presented in full color, and they incorporate many of the exciting scientific advances of the 15 years since the first edition. Second Edition [stated]. Presumed first printing this.…