Molecular Biophysics of the Extracellular Matrix

Morris, E R; Rees, D A; Arnott Struther (editors)

ISBN 10: 0896030512 / ISBN 13: 9780896030510

Published by Humana Press, Clifton, NJ, USA, 1984

About this Item

190pp. Green cloth-covered boards, gilt titles on spine. Spine sun faded, lightly bumped heel. Text block edges starting to fox. Previous owner's name on front free endpaper. Internally neat, clean, bright and tight. Dust jacket has light shelf wear. 8vo. Offers an extraordinary new interdisciplinary synthesis of what we know today about the molecular architecture and properties of the complex biological milieux in which cells exist and function.

Seller Inventory # 012093

Bibliographic Details

• Title: Molecular Biophysics of the Extracellular Matrix
• Publisher: Humana Press, Clifton, NJ, USA
• Publication Date: 1984
• Language: English
• ISBN 10: 0896030512
• ISBN 13: 9780896030510
• Binding: Hardcover
• Edition: 1st Edition.
• Condition: Very Good
• Dust Jacket Condition: Very Good
• Seller catalogs:
  • Science - Life Sciences, Biology, Human Biology...

About this title

Synopsis

Biopolymers, such as proteins and nucleic acids have been subjected to a rational succession of structural studies in which the determination of chemical compositions, link- ages, and sequences is followed by investigations of molecu- lar architecture and interactions. By the end of the 1960s the covalent structures of glycosaminoglycans and proteo- glycans had been defined both within the carbohydrate chains and in respect to their linkages to protein. The scene was therefore set for successful probing of three- dimensional shapes and intermolecular associations. For- tunately, during the 1970s appropriate physical methods were themselves greatly increasing in power. Consequently much progress has been made using X-ray diffraction anal- ysis of hydrated films, nuclear magnetic resonance spectro- scopy, and chromatographie methods for investigation of molecular interactions in solution. We now have a great deal of information about molecular shapes, their sensitiv- ity to environment (especially associated cations), and their modes of interaction that could be relevant to super- molecular assemblies in biological milieux. For these rea- sons we judged that it would be timely to distil the main conclusions from this phase of research to prepare for the next, which will involve detailed study of the interplay be- tween biological function and molecular structure. The idea for this volume emerged from a workshop meeting at Colworth sponsored by the Biochemical Society.