Synopsis
The neurobiology and mechanisms discovered in animals often do not translate to patients with a chronic pain condition. To help researchers and clinicians develop and use models that can help translate data from animals into humans, this book presents experimental animal models, with a focus on how they may translate into humans human experimental pain models, including details about pain induction and assessment human surrogate pain models clinical applications of pain models models that may link mechanisms of pain and pruritus
Pain Models contains 29 chapters by internationally recognized experts. It is a comprehensive survey of pain models at different levels, and commentaries by clinicians directly address clinical perspectives.
This unique book is unprecedented in its content. It's a quick reminder of the hard work needed to investigate the complex issue of pain perception. With the advent of increasingly sensitive noninvasive investigational tools, the authors want readers to know that basic research is still needed to help develop new drugs. This book will enrich anyone who wishes to know all that goes into conducting pain research with a lab-based pain model.
-- Tariq Malik, MD (University of Chicago Pritzker School of Medicine)
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About the Author
Professor Hermann O. Handwerker, Dr med, Dr med habil, Dr hc, is a retired professor of physiology at the University of Erlangen/Nürnberg. As head of the Department of Physiology and Pathophysiology, he supervised several research groups in different fields of pain research and in other areas of neurophysiology for more than two decades. From 1992 to 2004, he chaired the Special Research Unit of the Deutsche Forschungsgemeinschaft at the Universities of Erlangen and Würzburg. This unit comprised 18 preclinical and clinical research groups.
During his career as a physician and medical physiologist, he was research fellow at the Universities of Zürich and Edinburgh and a guest professor at the Universities of Leuven and Uppsala. In 1997, he became Dr. honoris causa of the Medical Faculty of the University of Uppsala.
In his early career, he worked experimentally on the peripheral and central mechanisms of nociception in anesthetized animals. Later, his main work concentrated on human studies in the field of microneurography of nociceptive nerve fibers in healthy subjects and in patients with neuropathies. Together with colleagues, he has published several hundred peer-reviewed papers and two monographs on pain (one with Manfred Zimmermann). He has edited several books and written chapters of several textbooks. Since 2004, he has been Editor-in-Chief of the European Journal of Pain.
Professor Lars Arendt-Nielsen, Dr Med Sci, PhD, is founder and director of the Center for Sensory Motor Interaction, an interdisciplinary international research and training center located at Aalborg University, Denmark . This internationally recognized center has at- tracted 80 scientists from all over the world (including many from Japan), and its PhD program has attracted more than 70 students, one-half of whom are international students.
The center s research focuses on (1) translational pain research; (2) human biomarkers for the assessment of pain from skin, muscles, and viscera in healthy volunteers and pain patients; (3) development of human pain biomarkers for screening of new analgesic compounds in humans (volunteers and patients); and (4) proof-of-concept and target validation studies on new analgesic compounds.
Today, Prof. Arendt-Nielsen presides over the largest and most productive pain research group in the world, and he is the leading international researcher in the field of interdisciplinary translational pain research.
Prof. Arendt-Nielsen s publication record counts 718 peer-reviewed papers and 13,974 citations with an H-factor of 56. He has delivered more than 210 keynote lectures at international meetings and seminars. In addition, he has helped establish a substantial network of international collaborations with universities and hospitals in 15 different countries and with the biomedical/pharmaceutical industry (20 international companies including several Japanese companies). Satellite laboratories have been established in six different countries.
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