Practical Process Research and Development

Neal G. Anderson

ISBN 10: 0120594757 / ISBN 13: 9780120594757

Published by Academic Press, 2000

Highlighting throughout the pages. Name written on side edge of the pages. Notes on endpapers. Otherwise in great condition. ; - We offer free returns for any reason and respond promptly to all inquiries. Your order will be packaged with care and ship on the same or next business day. Buy with confidence. Seller Inventory # HVD-32328-A-0

Synopsis:

This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students.

• Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules"
• Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more
• Includes over 100 tips for rapid process development
• Presents guidelines for implementing and troubleshooting processes

About the Author:

Neal G. Anderson is a synthetic organic chemist with over 40 years of experience in chemical process R&D in the pharmaceutical industry. He earned a B.S. degree in biology from the University of Illinois and a Ph.D. in medicinal chemistry from the University of Michigan, followed by industrial post-doctoral studies at McNeil Laboratories. He has extensive hands-on experience in the laboratory, pilot plant, and in manufacturing facilities. At Squibb / Bristol-Myers Squibb he made key contributions to processes for the manufacture of four major drug substances, including captopril, and has participated in 12 manufacturing start-ups and introductions of many processes to pilot plants. He received a BMS President's Award and spot awards, and his final position was Principal Scientist. In 1997, Anderson established Anderson’s Process Solutions L.L.C., a consulting firm based in the USA to offer practical guidance on developing and implementing processes for bulk pharmaceuticals and fine chemicals. As part of these consulting services, he presents courses on selected aspects of practical process R&D. He is experienced in laboratory research, scale-up, and technology transfer to ensure reproducibility and optimal product quality.

Bibliographic Details

Title: Practical Process Research and Development
Publisher: Academic Press
Publication Date: 2000
Binding: Hardcover
Condition: Good+
Dust Jacket Condition: No Dust Jacket As Issued
Edition: First Edition; Third Printing.