Study of the Antitoxic Effect of Unithiol on Cystamine in Dogs; DTRA-TR-07-46

41 pages (per Standard Form 298 [rev. 8-98]). Small ink notation on upper right corner of front cover. This includes a Conversion Table, abstract, Foreword, Tables, Section 1, Study of the Antitoxic Effect of Unithiol on Cystamine in Dogs. Section 2. Materials and Methods. Section 3. Results. Section 4. Discussion. Bibliography and Distribution List. The authors were with the Petersburg Nuclear Physics Institute, Gatchina, St. Petersburg, Russian Federation. The performing organization in the United States was ITT Corporation, Advanced Engineering & Sciences, Alexandria, VA. It was shown in experiments using a canine model that intramuscular administration of unithiol (monohydrate sodium salt of 2,3-dimerdapt-i-propansulfonic acid, 50 mg/kg) before cystamine (cystamine dihydrochloride, 100 mg/kg, calculation on the salt, intragastric administration) decreases the toxic effect of this radioprotector. The frequency of manifestations of the toxic effects of cystamine (change of behavior, vomiting reaction, decrease of body temperature and so on) is not decreased, but the severity of expression and duration are decreased. The period of agitation induced by cystamine is shortened, and the period and expression of vomiting induced by this preparation are decreased. Respiratory frequency and condition of the heart are lass changed (according to EKG data). The authors were the Head of Laboratory and Leading Research Worker, respectively of the Petersburg Nuclear Physics Institute, Gatchina, Leningrad District, Russia. This work was published in connection with a Defense Nuclear Agency contract. Founded in 1956 as a branch of the Ioffe Physico-Technical Institute, PNPI became an independent entity in 1971. The Institute, which is a part of the Russian Academy of Sciences, is a state research center. and is one of the four organizations comprising the pilot cooperation project at the National Research Center Kurchatov Institute, established in 2009. PNPI conducts research on neutron physics, high energy physics, theoretical physics, and molecular and radiation biophysics. Its primary activities in the area of nuclear physics include proton and small-angle diffraction scattering. It also conducts applied research in engineering, medicine, and ecology. The institute is home to a critical assembly and two research reactors, all of which are HEU-powered. The VVR-M reactor, commissioned in 1959, is one of the oldest in Russia. …