Understanding Organic Synthesis: A Systematic Approach to Reaction Classification

A unique and authoritative text on the fundamental principles of organic synthesis

Understanding Organic Synthesis unveils the logic of organic synthesis by identifying and explaining the similarities and analogies between reactions, as well as the underlying principles that determine how and why various types of organic compounds react. It demonstrates that a wide variety of reactions are either variants or specific examples of a small number of fundamental reactions.

After a brief introduction to the physicochemical principles of organic reactions, Understanding Organic Synthesis discusses:

• Classification of organic reactions into four main categories: nucleophilic, electrophilic, radical, and pericyclic reactions
• The impact of molecular structure on reactivity and the influence of external factors such as energy input, solvents, catalysts, and kinetic versus thermodynamic control
• Classification of nucleophilic agents and electron-deficient partners into five types each, creating 25 possible combinations, which are illustrated by key examples
• Classification of electrophilic agents into five and electron-rich partners into four types, creating 20 possible combinations, which are illustrated by key examples
• Ionic and radical reactions, supplemented by a discussion of pericyclic reactions

Understanding Organic Synthesis is an authoritative text for graduate students and organic chemists in academia and industry to deepen their understanding of reaction pathways that can be used to optimize the synthesis of targeted products or the design of new compounds.

Mieczyslaw Makosza was a professor of organic chemistry at the Faculty of Chemistry at Warsaw Technical University in Poland, and the Director of the Institute of Organic Chemistry at the Polish Academy of Sciences in Warsaw from 1979 until his retirement in 2004. He passed away in January 2026. He was a world-renowned expert in organic synthesis and one of the pioneers of phase-transfer catalysis. Another of his significant contributions to organic chemistry was the formulation of a general mechanism of nucleophilic aromatic substitution.

Michal Fedorynski was a professor of organic chemistry at Warsaw Technical University in Poland until he retired in 2016. His research interests include phase-transfer catalysis and the chemistry of carbanions and dihalocarbenes.