Using CNS Autopsy Tissue in Psychiatric Research: A Practical Guide

Hardcover, unused/unread, still in publisher's shrinkwrap. Minor handling wear, a dusty spot on outer page edges. -- x + 177 pages. An essential resource for researchers and clinicians in the field of psychiatry. This guidebook offers comprehensive methodologies for utilising central nervous system (CNS) autopsy tissues to study psychiatric disorders. Covering practical aspects such as tissue collection, preservation, and analysis, it emphasizes the importance of ethical considerations and the potential insights gained from post-mortem brain studies. The authors share their extensive expertise to enhance understanding of the biological basis of mental health conditions, ultimately contributing to the development of better treatments and interventions. -- Contents: Foreword; Contributors; The Collection of Tissue at Autopsy: Practical and Ethical Issues; Psychiatric Diagnosis After Death: The Problems of Accurate Diagnosis from Case History Review and Relative Interviews; Membrane Binding Assays: Membrane Preparation and Assay Development; The Localisation and Quantification of Molecular Changes in the Human Brain Using In Situ Radioligand Binding and Autoradiography; In Situ Hybridisation Histochemistry: Application to Human Brain Tissue; Immunohistochemistry Techniques Applicable for Use with Human Brain Tissue -- Essential for the laboratory, this practical manual presents a wide variety of techniques associated with the use of human CNS tissue obtained at autopsy. The book contains detailed methodologies in discrete chapters written by an expert in the specific field. It also addresses the potential for extending molecular studies in brain tissue obtained at autopsy into studies in living brain by using neuroimaging techniques. In addition, the reader is directed to suppliers of equipment and reagents that have been shown to be useful when studying human brain tissue.