Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk

De Serres, Frederick J., And William Sheridan, Editors

ISBN 10: 0306413809 / ISBN 13: 9780306413803

Published by Plenum Press, New York, 1983

An ex-library copy in dark blue cloth lettered in gold. The usual ex-libris markings, clean within. The binding is sound and there is little cover wear. No dust jacket. Seller Inventory # 040541

Synopsis:

The magnitude of the threat to the human genetic material posed by environmental agents has not as yet been fully determined. Never­ theless, the potential hazards of many chemicals have been identi­ fied by studies on lower organisms. However, too little is known regarding the comparability or lack of it between the metabolic pathways available in such organisms and those in man. Although at present there is great public concern for what is considered by some as the excessive use of laboratory animals in toxicological testing, it seems clear that the usage of mammalian systems may be deemed necessary. It has been proposed that cell culture systems might suffice to meet this need, however, such approaches cannot match the complexity of physiological occurances that are present in the intact animal. For studies of genetic effects, some non-invasive human test systems are presently available. These do not, however, meet the re­ quirements for extensive laboratory studies. In order to assess the risks to humans of environmental factors such laboratory investiga­ tions are essential. Therefore, for the forseeable future reliance on experiments using laboratory animals will be necessary. This Volume, which contains the proceedings of a workshop which was held at the National Institute of Environmental Health Sciences, March 29-31, 1982, explores the existing methodologies and their utility for risk estimations. It covers the most well developed human systems, as well as the most widely used animal tests.

Bibliographic Details

Title: Utilization of Mammalian Specific Locus ...
Publisher: Plenum Press, New York
Publication Date: 1983
Binding: Hardcover
Condition: Good
Dust Jacket Condition: No Dust Jacket
Edition: First Edition.
Book Type: Ex-Library