The Variation and Adaptive Expression of Antibodies

Cambridge, Massachusetts: Harvard University Press, 1973. We have only this one copy, but it is available now and ready to ship today from Henderson, Nevada. Fine condition in a bright and shiny but only Good dust jacket with rubbing, a few tiny chips and closed edge tears. Sharp corners. NO owner's name or bookplate. NOTa library discard. Pages are crisp, clean and unmarked. NO underlining. NO highlighting. NO margin notes. Bound in the original gilt-stamped rerd cloth. Complete with dust jacket. From an AI overview: "The Variation and Adaptive Expression of Antibodies is a 1973 scientific book by George P. Smith published by Harvard University Press. It explores the origins of antibody diversity using a computerized analysis of amino acid sequences from a molecular genetics perspective. Book Overview. Author: George P. Smith (later a Nobel Prize laureate in chemistry). Publication Year: 1973. Core Focus: Evaluating different theories on how the immune system creates antibody variety. Method: Computer-based analysis of amino acid sequences, like myeloma proteins, to trace evolution. Goal: Bridging the gap between molecular genetics and immunology." From the publisher: "During the past ten years, several theories have been proposed on the origin of the diversity of antibodies. George P. Smith presents a critical study of these theories in this detailed treatment of immunological problems from the point of view of molecular genetics. Mr. Smith uses a new and simplifying approach to this long-standing controversy. By a comprehensive computerized analysis of antibody amino acid sequences (particularly the myeloma proteins), the author traces their evolution and matches his results against the expectations of the various theories of diversity. He discusses at length the other types of evidence as well. Mr. Smith also deals with the clonal specialization of cells to produce a single antibody, and the relationship of this specialization to the somatic joining of antibody half-genes, which is one of the immune system's most important peculiarities. Introductory material is provided to make this work understandable to molecular geneticists not versed in immunology and to immunologists not versed in molecular genetics. This is a timely book offering a succinct and coherent summary of the various lines of evidence in a confused and controversial field.". First Edition. Hardcover. Fine condition/Good dust jacket. Illus. by NOT a library discard. 8vo. xiv, 219pp. Great Packaging, Fast Shipping. …