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1 vol. gd.in-8 (24.5 x 17.5 cm), XII, 268 pp., 106 figures dans le texte, demi-basane havane moderne, dos à nerfs, pièces de titre vertes (Brauner NEUEREM HALBLEDER, rücken mit bünden, grüne rückenschild), cachet (STEMPEL) "Geschenk der Frau Geheimrat Schele, 1903" sur la page de titre et cachet de la "Chirurgische klinik der Rhein universitat" au titre et sur une dizaine de pages (STEMPEL AUF UNGEFAHR ZEHN SEITEN), par ailleurs exemplaire en très bon état (SONST BUCH IN SEHR GUTEM ZUSTAND). Deuxième édition, corrigée et augmentée, avec des données novatrices et fondamentales (notamment sur l'histopronostic des tumeurs), de loin la plus importante et la plus rare (la première édition a paru en 1897). GANZ UMGEARBEITETE UND VERMEHRTE AUSFLAGE, MIT INNOVATIVEN UND GRUNDLEGENDEN DATEN, BEI WEITEM DIE WICHTIGSTEN UND SELTENSTEN. David Paul von Hansemann (1858-1920), élève de Virchow, devint en 1897 professeur de pathologie à l'Université de Berlin. REFERENCES : Haagensen CD : An Exhibit of important books, papers, and memorabilia illustrating the evolution of the knowledge of cancer, 103: "Von Hansemann originated the concept of anaplasia. He was able to correlate the degree of anaplasia, or departure from an adult, highly differentiated histologic type, with the degree of clinical malignancy of carcinoma. He was thus the founder of the modern movement which attempts to grade tumors as to their malignancy. This book presents his theory in its definitive form. It is, moreover, one of the best discussions of the histologic diagnosis of tumors ever written."; Garrison & Morton, 2626: "Hansemann originated the theory of anaplasia.";Dhom G: Geschichte der Histopathologie, pp. 179-183, 747: "Von eminent praktischer Bedeuntung ist Hansemann schrifts über die mikroskopisc Stellung, deren Notwendigkeit Stellung, deren Notwendigkeit er freilich nicht generell leugnetten Auflage (1897) wesentlich umgestalteten und erwiterten 2. Auflage von 1902 gibt Hansemann zahlreiche diagnostische Hinweise, die bis heute ihre Gültigkeit behalten haben." ; Shimkin MB: Contrary to nature, p. 189; Damjanov I: History and general aspects of tumor grading, Cancer Grading Manual (2013), pp. 1-2: "The first attempts to correlate the microscopic features of tumors with their biology and clinical behavior are traditionally attributed to David Paul von Hansemann (1858?1920). This German pathologist, who was a student of Virchow, studied systematically the microscopic pathology of tumors and in the 1890s published his pioneering observations on abnormal mitotic figures. He also introduced the terms anaplasia and dedifferentiation (German: Entdifferenzirung) and was the first to suggest that the clinical behavior of tumors could be predicted from their microscopic characteristics. In contrast to many theoretical textbooks dominating the field of pathology, this treaty was based on meticulous microscopic study of tumors and could be considered 'evidence based.' It was illustrated with original drawings supporting the author?s views of cancer. The clarity of these illustrations is fascinating even today."; Hardy PA & Zacharias H: Reappraisal of the Hansemann?Boveri hypothesis on the origin of tumors, Cell Biol Int. 2005 Dec;29(12):983-92: "David Hansemann [1858?1920] and Theodor Boveri [1862?1915] were major contributors to early debates on the relationship between chromosomal defects, tumorigenesis and malignancies."; Bignold LP, ?Coghlan BLD & Jersmann HPA: David Paul von Hansemann, Contributions to Oncology. Seller Inventory # 231464
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