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Dendritic cells in human atherosclerosis: Focus on dendritic cell activation and oxidative stress - Softcover
Atherosclerosis is the main cause of death in the Western world. The importance of the immune system in the pathogenesis of atherosclerosis is now widely accepted. Here, we demonstrated that circulating dendritic cells (DC) – the most professional antigen-presenting cells in the body - decline in coronary artery disease patients. This is - at least partly - due to impaired differentiation from bone marrow progenitors, but can also be explained by activation and subsequent migration to atherosclerotic plaques or lymph nodes. To be able to exert their function at inflammatory sites, DC need to be resistant to cell death induced by proatherogenic factors, such as oxLDL. Monocyte-derived DC seem to have an effective antioxidant defense system in comparison with monocytes, with high protein levels of peroxiredoxin 2 and glutathione peroxidase 3 among others. This enables them to survive in highly oxidative environments. Whether they enhance or delay the atherosclerotic process, or whether they are differently involved in the various stages of the disease, remains to be established. This book may be useful for anyone who is interested in the immunological aspects of atherosclerosis.
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About the Author:
Ilse Van Brussel, PhD. Graduated in 2007 as Master in Biomedical Sciences, then started a PhD at the lab of molecular and cellular cardiology (University of Antwerp) to explore the role of dendritic cells in atherosclerosis. Currently working as a postdoc at the lab of pharmacology, University of Antwerp.
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- PublisherLAP LAMBERT Academic Publishing
- Publication date2012
- ISBN 10 3659235407
- ISBN 13 9783659235405
- BindingPaperback
- Number of pages232
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Dendritic cells in human atherosclerosis: Focus on dendritic cell activation and oxidative stress
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Atherosclerosis is the main cause of death in the Western world. The importance of the immune system in the pathogenesis of atherosclerosis is now widely accepted. Here, we demonstrated that circulating dendritic cells (DC) the most professional antigen-presenting cells in the body - decline in coronary artery disease patients. This is - at least partly - due to impaired differentiation from bone marrow progenitors, but can also be explained by activation and subsequent migration to atherosclerotic plaques or lymph nodes. To be able to exert their function at inflammatory sites, DC need to be resistant to cell death induced by proatherogenic factors, such as oxLDL. Monocyte-derived DC seem to have an effective antioxidant defense system in comparison with monocytes, with high protein levels of peroxiredoxin 2 and glutathione peroxidase 3 among others. This enables them to survive in highly oxidative environments. Whether they enhance or delay the atherosclerotic process, or whether they are differently involved in the various stages of the disease, remains to be established. This book may be useful for anyone who is interested in the immunological aspects of atherosclerosis. 232 pp. Englisch. Seller Inventory # 9783659235405
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Book Description Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Van Brussel IlseIlse Van Brussel, PhD. Graduated in 2007 as Master in Biomedical Sciences, then started a PhD at the lab of molecular and cellular cardiology (University of Antwerp) to explore the role of dendritic cells in atheroscl. Seller Inventory # 5141896
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Dendritic cells in human atherosclerosis : Focus on dendritic cell activation and oxidative stress
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Atherosclerosis is the main cause of death in the Western world. The importance of the immune system in the pathogenesis of atherosclerosis is now widely accepted. Here, we demonstrated that circulating dendritic cells (DC) the most professional antigen-presenting cells in the body - decline in coronary artery disease patients. This is - at least partly - due to impaired differentiation from bone marrow progenitors, but can also be explained by activation and subsequent migration to atherosclerotic plaques or lymph nodes. To be able to exert their function at inflammatory sites, DC need to be resistant to cell death induced by proatherogenic factors, such as oxLDL. Monocyte-derived DC seem to have an effective antioxidant defense system in comparison with monocytes, with high protein levels of peroxiredoxin 2 and glutathione peroxidase 3 among others. This enables them to survive in highly oxidative environments. Whether they enhance or delay the atherosclerotic process, or whether they are differently involved in the various stages of the disease, remains to be established. This book may be useful for anyone who is interested in the immunological aspects of atherosclerosis. Seller Inventory # 9783659235405
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Dendritic cells in human atherosclerosis Focus on dendritic cell activation and oxidative stress
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