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An RNA regulates the epigenetic switch at the basis of FSHD: A Polycomb/Trithorax Epigenetic Switch in Muscular Dystrophy - Softcover
FSHD is an autosomal dominant disease associated with contraction of D4Z4 repeats, mapping to 4q35. By an unknown mechanism, D4Z4 deletion causes an epigenetic switch leading to de-repression of 4q35 genes. Repression by D4Z4 displays similarities with Polycomb-mediated silencing. Polycomb (PcG) and Trithorax (TrxG) group proteins work as counteractors in the epigenetic regulation of gene expression. Transcription of PcG-binding regions can regulate PcG activity. Intriguingly, it is shown here that D4Z4 generates a chromatin-bound RNA selectively in FSHD patients and upon 4q35 de-repression. This transcript is specifically 4q35-associated and is required for 4q35 gene de-repression. Interestingly, the identified RNA promotes the recruitment of the TrxG protein Ash1L to the FSHD locus. Notably, Ash1L is necessary for 4q35 gene de-repression. These results suggest that the RNA functions by recruiting Ash1L to counteract PcG silencing at D4Z4 leading to 4q35 gene de-repression in FSHD. This work provides a nexus for revealing the epigenetic basis of FSHD etiology. Moreover, this study gives insights into the biological function of repetitive elements.
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Dr. Daphne S. Cabianca was born in Italy on 19th February 1982. In 2006 she obtained the Degree in Experimental and Applied Biology at the University of Pavia, Italy, full marks with honours. In 2011 she obtained the PhD in Molecular and Cellular Biology, International PhD Program at the Vita-Salute University, Italy and Open University, UK.
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- PublisherLAP LAMBERT Academic Publishing
- Publication date2012
- ISBN 10 3846528129
- ISBN 13 9783846528129
- BindingPaperback
- Number of pages116
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An RNA regulates the epigenetic switch at the basis of FSHD: A Polycomb/Trithorax Epigenetic Switch in Muscular Dystrophy
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An RNA Regulates the Epigenetic Switch at the Basis of Fshd
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An RNA regulates the epigenetic switch at the basis of FSHD A PolycombTrithorax Epigenetic Switch in Muscular Dystrophy
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An RNA regulates the epigenetic switch at the basis of FSHD
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -FSHD is an autosomal dominant disease associated with contraction of D4Z4 repeats, mapping to 4q35. By an unknown mechanism, D4Z4 deletion causes an epigenetic switch leading to de-repression of 4q35 genes. Repression by D4Z4 displays similarities with Polycomb-mediated silencing. Polycomb (PcG) and Trithorax (TrxG) group proteins work as counteractors in the epigenetic regulation of gene expression. Transcription of PcG-binding regions can regulate PcG activity. Intriguingly, it is shown here that D4Z4 generates a chromatin-bound RNA selectively in FSHD patients and upon 4q35 de-repression. This transcript is specifically 4q35-associated and is required for 4q35 gene de-repression. Interestingly, the identified RNA promotes the recruitment of the TrxG protein Ash1L to the FSHD locus. Notably, Ash1L is necessary for 4q35 gene de-repression. These results suggest that the RNA functions by recruiting Ash1L to counteract PcG silencing at D4Z4 leading to 4q35 gene de-repression in FSHD. This work provides a nexus for revealing the epigenetic basis of FSHD etiology. Moreover, this study gives insights into the biological function of repetitive elements. 116 pp. Englisch. Seller Inventory # 9783846528129
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An RNA regulates the epigenetic switch at the basis of FSHD : A Polycomb/Trithorax Epigenetic Switch in Muscular Dystrophy
Published by
LAP LAMBERT Academic Publishing
(2012)
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ISBN 13: 9783846528129
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - FSHD is an autosomal dominant disease associated with contraction of D4Z4 repeats, mapping to 4q35. By an unknown mechanism, D4Z4 deletion causes an epigenetic switch leading to de-repression of 4q35 genes. Repression by D4Z4 displays similarities with Polycomb-mediated silencing. Polycomb (PcG) and Trithorax (TrxG) group proteins work as counteractors in the epigenetic regulation of gene expression. Transcription of PcG-binding regions can regulate PcG activity. Intriguingly, it is shown here that D4Z4 generates a chromatin-bound RNA selectively in FSHD patients and upon 4q35 de-repression. This transcript is specifically 4q35-associated and is required for 4q35 gene de-repression. Interestingly, the identified RNA promotes the recruitment of the TrxG protein Ash1L to the FSHD locus. Notably, Ash1L is necessary for 4q35 gene de-repression. These results suggest that the RNA functions by recruiting Ash1L to counteract PcG silencing at D4Z4 leading to 4q35 gene de-repression in FSHD. This work provides a nexus for revealing the epigenetic basis of FSHD etiology. Moreover, this study gives insights into the biological function of repetitive elements. Seller Inventory # 9783846528129
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An RNA regulates the epigenetic switch at the basis of FSHD A PolycombTrithorax Epigenetic Switch in Muscular Dystrophy
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An RNA regulates the epigenetic switch at the basis of FSHD
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Cabianca Daphne S.Dr. Daphne S. Cabianca was born in Italy on 19th February 1982. In 2006 she obtained the Degree in Experimental and Applied Biology at the University of Pavia, Italy, full marks with honours. In 2011 she obtained th. Seller Inventory # 5496843
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