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QSAR Based Design & Synthesis: Design, Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives - Softcover
We carried out a QSAR study on benzotriazine derivatives & studied 28 potent GABAA receptor ligands; derivatives of benzotriazines, using a combination of various physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features with potent anticonvulsant activity. Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity.
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About the Author:
Priyal Jain Asst. Prof Sagar Institute of Research and Technology-Pharmacy, Bypass Road, Bhopal-462036 (M.P), India. He has devoted their work to develop different 3D & 2D QSAR models for drug design.
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- PublisherLAP LAMBERT Academic Publishing
- Publication date2012
- ISBN 10 3846586021
- ISBN 13 9783846586020
- BindingPaperback
- Number of pages76
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QSAR Based Design & Synthesis: Design, Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -We carried out a QSAR study on benzotriazine derivatives & studied 28 potent GABAA receptor ligands; derivatives of benzotriazines, using a combination of various physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features with potent anticonvulsant activity. Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity. 76 pp. Englisch. Seller Inventory # 9783846586020
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QSAR Based Design & Synthesis : Design, Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - We carried out a QSAR study on benzotriazine derivatives & studied 28 potent GABAA receptor ligands; derivatives of benzotriazines, using a combination of various physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features with potent anticonvulsant activity. Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity. Seller Inventory # 9783846586020
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QSAR Based Design Synthesis Design, Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Jain PriyalPriyal Jain Asst. Prof Sagar Institute of Research and Technology-Pharmacy, Bypass Road, Bhopal-462036 (M.P), India. He has devoted their work to develop different 3D & 2D QSAR models for drug design.We carried out a Q. Seller Inventory # 5501408
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