The role of the Hr gene in brain, gut and thymus development in the mouse | Gene Hr (Hairless)

Olga Tacius (u. a.)

ISBN 10: 6203500003 / ISBN 13: 9786203500004

Published by Our Knowledge Publishing, 2021

About this Item

The role of the Hr gene in brain, gut and thymus development in the mouse | Gene Hr (Hairless) | Olga Tacius (u. a.) | Taschenbuch | Englisch | 2021 | Our Knowledge Publishing | EAN 9786203500004 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 120486702

Bibliographic Details

• Title: The role of the Hr gene in brain, gut and thymus development in the mouse | Gene Hr (Hairless)
• Publisher: Our Knowledge Publishing
• Publication Date: 2021
• Language: English
• ISBN 10: 6203500003
• ISBN 13: 9786203500004
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 4D millimeters 220 millimeters width by 150 millimeters height by 4 millimeters depth
• Weight: 113 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

The mechanisms of genetic control of organ embryogenesis by WNT- and BMP-dependent gene networks have been studied only in general terms. However, the expression of many genes also involved in organogenesis correlates with the expression of genes of Wnt and Bmp families and their effectors. In particular, one of such genes is Hr (Hairless) gene. Mutation in the Hr gene in mice leads to the development of a characteristic phenotype expressed in complete baldness by three weeks of age. Also, adult mice carrying the mutant allele of the Hr gene in the homozygote show anatomical defects in the thymus, inner ear, brain and intestine, organs whose tissues express the normal Hr gene in heterozygotes and wild-type animals. The formation of these organs occurs during embryogenesis and is controlled by poorly understood molecular mechanisms. Inductive interactions between epithelial and mesenchymal components of embryonic setting play an important role in the regulation of their development.The aim of this work is to find out whether the normal allele of Hr gene affects the functioning of WNT- and BMP-dependent gene networks in the embryogenesis of epithelio-mesenchymal organs in mouse.