The role of neutrophil extracellular traps (NETs) in the pathogenesis and differentiation of equine asthma phenotypes

Language: English

Published by Cuvillier, Cuvillier Apr 2025, 2025

3689527287 / 9783689527280

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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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Softcover

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This item is printed on demand - it takes 3-4 days longer - Neuware -Equine asthma (EA) is the most prevalent chronic lung disease in horses. The immunological processes are only partially understood. Neutrophils are the primary effector cell in severe EA (sEA) and essential components of the innate immune defence. One defence mechanism is the release of neutrophil extracellular traps (NETs). NETs have the ability to capture and kill pathogens; however, they can also contribute to autoimmune responses, chronic inflammation and host damage if not properly regulated. The aim of this study was to characterise the role of NETs in the pathogenesis of EA. Analysis of BALF revealed the highest numbers of NET activated cells in sEA, in addition to elevated levels of equine cathelicidin and reduced DNase activity. Isolated blood neutrophils from horses with EA showed increased NET formation in vitro, which correlated with the clinical severity and a decrease in the cellular cholesterol content. Neutrophil cholesterol further correlated with clinical parameters associated with disease severity. The presence of circulating anti-neutrophil cytoplasmic antibodies (ANCAs) suggested local and systemic NET-related alterations. The findings of this study provide novel insights into immunological alterations in EA, with potential for the development of diagnostic and therapeutic strategies targeting NET formation and associated immune dysfunction. 182 pp. Englisch. …

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Bibliographic details

Title
The role of neutrophil extracellular traps (NETs) in the pathogenesis and differentiation of equine asthma phenotypes
Author
Lia Kristin Meiseberg
Publisher
Cuvillier, Cuvillier Apr 2025
Publication year
2025
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3689527287
ISBN 13
9783689527280
Item weight
244 grams
Dimensions
210x148x10 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

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BuchWeltWeit Ludwig Meier e.K.

Germany