"Polynucleotide Synthesis and the Genetic Code". Reprinted from the Harvey Lectures, Series 62, pp. 79-105. SIGNED BY GOBIND KHORANA.

KHORANA, H. G. [Har Gobind]

Published by New York & London: Academic Press, 1968.

About this Item

Pp. 79-105. Original printed wrappers. Stapled as issued. Near Fine. First Edition. SIGNED BY GOBIND KHORANA: "Best wishes/ Gobind Khorana". Harvey Lecture delivered November 17, 1966. Khorana shared the Nobel Prize in Physiology or Medicine in 1968 with Robert W. Holley and Marshall W. Nirenberg "for their interpretation of the genetic code and its function in protein synthesis." Khorana published three papers with the same title "Polynucleotide Synthesis and the Genetic Code". The first was in 1965: H. G. Khorana, "Polynucleotide Synthesis and the Genetic Code", Federation Proceedings, Vol. 24, 1965, pp. 1473-1487. The second was the multi-authored paper from the Cold Spring Harbor "Genetic Code" Symposium in June 1966, Cold Spring Harbor Symposia on Quantitative Biology, Vol. 31, 1966, pp. 39-49. The last was the paper offered here, which was Khorana's Harvey Lecture delivered on November 17, 1966. "Khorana made one of the most consequential advances in molecular biology by using a hybrid approach that employed organic chemistry to synthesize short sequence of a few nucleotides followed by the use of a copying enzyme to generate long DNA molecules with many repeating copies of the short sequence. Khorana's molecules with a repeating sequence were the keys to cracking the genetic code. A few years earlier, the complex process of translation was reconstituted in the test tube and was dependent on messenger RNA added from the outside. By using synthetic messenger RNAs to instruct the synthesis of proteins by the ribosome, Khorana's group was able to work out rules for how specific sequences of three nucleotides in RNA are translated into the 20 possible amino acids" (Chris Kaiser, "Gobind Khorana and the Rise of Molecular Biology", which can be read online for free). Seller Inventory # 17259

Bibliographic Details

Title: "Polynucleotide Synthesis and the Genetic ...

Publisher: New York & London: Academic Press, 1968.

Binding: Soft cover

Condition: Near Fine

Signed: Signed by Author(s)

Edition: 1st Edition