A sleep-promotion nucleus in midbrain

Su-Rong Yang

ISBN 10: 6139948843 / ISBN 13: 9786139948840

Published by LAP LAMBERT Academic Publishing Jan 2019, 2019

About this Item

Neuware -Sleep¿wake behavior is controlled by networks of neurons and neurotransmitters in the brain. There are multiple populations of wake-promoting neurons, but few sleep-promoting neurons have been identified. In this study, we revealed that the rostromedial tegmen-talnucleus, the GABAergic tail of the ventral tegmental area,regulates non-rapideye movement sleep. We show that neurons in the rat rostromedial tegmental nucleus, when activated by pharmacogenetics, increase and deepen non-rapid eye movement sleep. Inhibition of these neurons exhibits the opposite effects. Furthermore, rats with lesion in the rostromedial tegmental nucleus have a reduced response of sleep homeostasis following sleep deprivation. We show that stimulation of the terminals of the neurons in the rostromedial tegmental nucleus inhibits dopaminergic neurons in the midbrain. Interestingly, inhibition of these dopaminergic neurons also has sleep-promoting effects. The current results provide a potential target for prolonging non-rapid eye movement sleep, improving sleep quality, and treating sleep disorders in dopamine-implicated mental illness.Books on Demand GmbH, Überseering 33, 22297 Hamburg 56 pp. Englisch.

Seller Inventory # 9786139948840

Bibliographic Details

• Title: A sleep-promotion nucleus in midbrain
• Publisher: LAP LAMBERT Academic Publishing Jan 2019
• Publication Date: 2019
• Language: English
• ISBN 10: 6139948843
• ISBN 13: 9786139948840
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 4D millimeters 220 millimeters width by 150 millimeters height by 4 millimeters depth
• Weight: 102 grams

About this title

Synopsis

Sleep–wake behavior is controlled by networks of neurons and neurotransmitters in the brain. There are multiple populations of wake-promoting neurons, but few sleep-promoting neurons have been identified. In this study, we revealed that the rostromedial tegmen-talnucleus, the GABAergic tail of the ventral tegmental area,regulates non-rapideye movement sleep. We show that neurons in the rat rostromedial tegmental nucleus, when activated by pharmacogenetics, increase and deepen non-rapid eye movement sleep. Inhibition of these neurons exhibits the opposite effects. Furthermore, rats with lesion in the rostromedial tegmental nucleus have a reduced response of sleep homeostasis following sleep deprivation. We show that stimulation of the terminals of the neurons in the rostromedial tegmental nucleus inhibits dopaminergic neurons in the midbrain. Interestingly, inhibition of these dopaminergic neurons also has sleep-promoting effects. The current results provide a potential target for prolonging non-rapid eye movement sleep, improving sleep quality, and treating sleep disorders in dopamine-implicated mental illness.