In vitro model systems to study single and collective cell migration

Claudio G. Rolli

ISBN 10: 3838139569 / ISBN 13: 9783838139562

Published by Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Mai 2016, 2016

About this Item

This item is printed on demand - it takes 3-4 days longer - Neuware -Cell migration is an essential characteristic of both physiological and pathological processes within the human body. In order to study the complex process of cell migration different in vitro model systems have been developed in the past. The challenge for all these assays is to provide the cells a substrate that mimics particular properties of the extracellular matrix while a high control over experimental parameters and monitoring is desired. However, migration assays commonly used in cell biology and medical research are rather limited in the control over the architecture of the provided matrix on or through which the cells move or by the lack of adequate imaging devices to monitor cell dynamics. To overcome some limitations of conventional migration assays, it was the aim of this work to develop two different methods and employ them in order to quantify migrative behavior of cells under precisely controlled in vitro conditions. 180 pp. Englisch.

Seller Inventory # 9783838139562

Bibliographic Details

• Title: In vitro model systems to study single and collective cell migration
• Publisher: Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Mai 2016
• Publication Date: 2016
• Language: English
• ISBN 10: 3838139569
• ISBN 13: 9783838139562
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 12D millimeters 220 millimeters width by 150 millimeters height by 12 millimeters depth
• Weight: 286 grams

About this title

Synopsis

Cell migration is an essential characteristic of both physiological and pathological processes within the human body. In order to study the complex process of cell migration different in vitro model systems have been developed in the past. The challenge for all these assays is to provide the cells a substrate that mimics particular properties of the extracellular matrix while a high control over experimental parameters and monitoring is desired. However, migration assays commonly used in cell biology and medical research are rather limited in the control over the architecture of the provided matrix on or through which the cells move or by the lack of adequate imaging devices to monitor cell dynamics. To overcome some limitations of conventional migration assays, it was the aim of this work to develop two different methods and employ them in order to quantify migrative behavior of cells under precisely controlled in vitro conditions.

About the Author

Claudio G. Rolli graduated from Ruprecht-Karls University Heidelberg, Germany (Dipl.-Chemiker). He carried out his doctorate studies at the Max Planck Institute for Intelligent Systems, Stuttgart, Germany and the National Institute for Materials Science in Tsukuba, Japan and graduated from the Ruprecht-Karls University Heidelberg (Dr. rer. nat.).