Medicinal Chemistry: A Biochemical Approach - Softcover

Nogrady, Thomas

Softcover

ISBN 10: 0195053699 ISBN 13: 9780195053692

Publisher: Oxford University Press, 1988

Synopsis

Emphasizing the molecular action of drugs, this text incorporates recent findings from biochemical pharmacology along with the latest insights into the interactions of drugs with their receptors. It is organized by targets of drug action--endogenous messengers and their receptors, membranes, enzymes, and DNA, among others--and covers all drug groups and their therapeutic applications. This new edition has been thoroughly revised to provide expanded coverage of co-transmitters and neurohormones as well as adenosine receptors and calcium channel blockers. The chapter on drug distribution and metabolism has been extended, and the final chapter on principles of drug design outlines new methods, such as numerical techniques and computer graphics. Other new topics include atrial natriuretic factors, antiarrhythmic drugs, and DNA topoisomerase inhibitory mechanism of antitumor and antibacterial agents. The text is illustrated with hundreds of formulas and tables, and the index includes an extensive listing of drugs.

About this title

About the Author:

Thomas Nogrady is at Concordia University.

Review:

"The text is very readable and each chapter has a bibliography for further reading. The book will be very useful for those wishing to understand the mechanisms of drug action and how to design new drugs." --International Journal of Biochemistry

"Despite the intense interest in medicinal chemistry, there have been surprisingly few useful texts available . . . Almost all have been organized and oriented along the same lines, namely a discussion of drugs by pharmacological class. This effort by Thomas Nogrady represents a major and
refreshing departure from this format by emphasizing the biochemical basis of drug action . . . The book is a welcome and refreshing approach to the presentation of medicinal chemistry and should prove valuable." --Journal of Pharmaceutical Sciences (on the first edition)

"Useful as an introductory book or a quick reference for medicinal chemists." --Journal of the American Chemists Society

"The approach to medicinal chemistry presented in this book fills a void found in most medicinal chemistry textbooks. Its contents is very informative and this textbook should be utilized as a primary reference for undergraduate medicinal chemistry courses. Because of its excellent
organization and the up-to-date content, this textbook could serve as a textbook for graduate courses in introductory medicinal chemistry as well as for one which focuses on neurotransmitters, hormones and nonmessenger targets for drug action. This book would be a valuable addition to any library
that supports programs in medicinal chemistry or the other pharmaceutical sciences." --American Journal of Pharmaceutical Education

"Includes a very comprehensive discussion of chemical and physical properties of drugs, and the general principles involved in their design. It also has a nice discussion on the biochemical basis of their action, including alot of relevant background information on the systems involved--for
example, nice sections on the biochemistry of hormone/receptor function, the biochemistry of neurotransmitters, and so on. Another useful feature is a list of drugs at the end of the book. . . .good for medically minded biochemists and scientifically minded medical students." --New Scientist

"The text is very readable and each chapter has a bibliography for further reading. The book will be very useful for those wishing to understand the mechanism of drug action and how to design new drugs." --Gen. Pharmac.

"The text is very readable and each chapter has a bibliography for further reading. The book will be very useful for those wishing to understand the mechanisms of drug action and how to design new drugs." --Comparative Biochemistry and Physiology

"A concise review of the topic that is enhanced by several well chosen examples and numerous diagrams.. . . the author has highlighted the major findings in each area in a succinct, readable style, and has provided the reader with key references to recent reviews at the end of each section."
--Drug Intelligence and Clinical Pharmacy

About this edition

• Publisher: Oxford University Press
• Publication date: 1988
• ISBN 10: 0195053699
• ISBN 13: 9780195053692
• Binding: Paperback
• Edition number: 2
• Number of pages: 542