Neuronal Development (Current Topics in Neurobiology) - Hardcover

Hardcover

ISBN 10: 0306409569 ISBN 13: 9780306409561

Publisher: Springer, 1982

Synopsis

1. Cell Lineage in the Development of the Leech Nervous System.- 1. Introduction.- 1.1. Developmental Cell Lineages.- 1.2. The Leech Nervous System.- 2. Leech Embryogenesis.- 2.1. Two Experimentally Favorable Leech Species.- 2.2. A Developmental Staging System.- 3. A Novel Cell Lineage Tracing Method.- 3.1. Horseradish Peroxidase Tracer.- 3.2. Fluorescent Tracer.- 4. Development of Germinal Bands.- 4.1. Ectodermal Stem Cell Bandlets.- 4.2. Mesodermal Stem Cell Bandlets.- 5. Origin of the Segmental Ganglia.- 5.1. Ectoteloblast Contribution.- 5.2. Distribution Pattern of Four Neuronal Kinship Groups.- 5.3. Number of Ganglion Founder Cells.- 5.4. Mesoteloblast Contribution.- 5.5. Origin of the Supraesophageal Ganglion.- 6. Cell-Specific Ablation.- 6.1. Role of Mesoderm in Ectodermal Development.- 6.2. Role of Ectoderm in Mesodermal Development.- 6.3. Morphogenetic Interactions within the Ectoderm.- 7. Conclusion.- 7.1. Governance of Cell Fate by Cell Lineage.- 7.2. Neuronal Kinship Groups.- 7.3. Segmentation.- 8. References.- 2. Origins of the Nervous System in Amphibians.- 1. Introduction.- 2. The Theory of Compartmentation.- 3. Predictions Made from the Theory and Their Experimental Verification.- 3.1. Deployment of Labeled Clones after HRP Injection into Ancestral Cells at Various Stages.- 3.2. Origins of Compartment-Specific Properties.- 3.3. Relation of Compartment Founder Cell Groups to Differentiated Cell Types.- 4. Critique of the Theory of the Organizer.- 4.1. Preliminary Considerations.- 4.2. Early Experimental Tests.- 4.3. Recent Experimental Tests with HRP Label.- 5. Compartment vs. Organizer Theories.- 5.1. The Case for the Compartment Theory.- 5.2. Difficulties with the Organizer Theory.- 6. References.- 3. Monoclonal Antibodies to Embryonic Cell-Specific Markers for Chick Ciliary Ganglion.- 1. Introduction.- 1.1. Formation of Complex Connections in the Nervous System.- 1.2. Antibodies as Cytochemical Markers of Neuronal Cells.- 1.3. The Ciliary Ganglion, a Model of Neuronal Development in Vertebrates.- 2. Materials and Methods.- 2.1. Dissociated Cell Cultures.- 2.2. Immunological Procedures.- 2.3. Reagents.- 3. Results.- 3.1. Initial Selection and Cloning of Antibody-Producing Hybrids.- 3.2. Monoclonal Antibodies Specific for CG Neurons.- 3.3. Staining of Cranial Neural Crest Cells in Vitro.- 3.4. Cytotoxicity of CG-1.- 3.5. Other Monoclonal Antibodies.- 3.6. Blocking Studies.- 4. Discussion.- 4.1. The Specificity of These Monoclonal Antibodies.- 4.2. Possible Identification of CG Neuron Precursors.- 4.3. Independence and Identity of the Antigenic Determinants.- 4.4. Potential Heterogeneity of CG Neurons.- 5. References.- 4. Genetic Manipulation of Sensory Pathways in Drosophila.- 1. Introduction.- 1.1. Levels of Analysis.- 1.2. Advantages of Different Organisms.- 1.3. What Understanding Can We Gain from Genetic Manipulation?.- 2. The Experimental Material.- 2.1. Mutants.- 2.2. Mosaics.- 3. A Theoretical Framework.- 3.1. Binary Decisions.- 3.2. The Bithorax Complex.- 3.3. The Antennapedia Complex.- 3.4. Compartments.- 3.5. Evaluation.- 3.6. Working Hypotheses and Questions for Neurobiologists.- 4. Compartments Boundaries and Peripheral Nerves.- 4.1. General Neuroanatomy of Drosophila.- 4.2. Neuroanatomy of the Wing.- 4.3. The Behavior of Axons at the A-P Compartment Border.- 4.4. Evidence That the Compartment Border Is Intact.- 4.5. The Next Hypothesis-Pupal Nerves Guide Adult Axons.- 4.6. Evaluation.- 5. Central Projections in Mutants of the Antennapedia Complex.- 5.1. Antennapedia.- 5.2. Proboscipedia.- 5.3. Interpretation.- 6. Central Projections in Mutants of the Bithorax Complex.- 6.1. Different Classes of Receptors Form Different Projections.- 6.2. The Projection of Single Axons Is Not Always Precisely Specified.- 6.3. Axons from the Normal Wings of Mutant Flies Branch More.- 6.4. Some Axons from Homeotic Wings Follow Normal Wing Tracts.- 6.5. Some Axons from Homeotic Wings Follow Haltere Tracts.- 6.

Edition details

• Publisher: Springer
• Publication date: 1982
• Language: English
• ISBN 10: 0306409569
• ISBN 13: 9780306409561
• Binding: Hardcover
• Edition number: 1
• Number of pages: 478
• Editor: Spitzer Nicholas C.