Contractile Mechanisms in Muscle (Advances in Experimental Medicine & Biology) - Hardcover

Pollack, Gerald And Haruo Sugi:

Hardcover

ISBN 10: 0306416115 ISBN 13: 9780306416118

Publisher: New York: Plenum 1984. (Advances in Experimental Medicine and Biology), 1984

Synopsis

Prior to the emergence of the sliding filament model, contraction theories had been in abundance. In the absence of the kinds of structural and biochemical information available today, it has been a simple matter to speculate about the possible ways in which tension generation and shortening might occur. The advent of the sliding filament model had an immediate impact on these theories; within several years they fell by the wayside, and attention was redirected towards mechanisms by which the filaments might be driven to slide by one another. In terms of identifying the driving mechanism, the pivotal observa­ tion was the electron micrographic indentification of cross-bridges extending from the thick filaments. It was quite naturally assumed that such bridges, which had the ability to split ATP, were the molecular motors, i.e., that they were the sites of mechanochemical transduction. Out of this presumption grew the cross-bridge model. in which filament sliding is presumed to be driven by the cyclic interaction of cross-bridges with complementary actin sites located along the thin filaments.

About this edition

• Publisher: New York: Plenum 1984. (Advances in Experimental Medicine and Biology)
• Publication date: 1984
• ISBN 10: 0306416115
• ISBN 13: 9780306416118
• Binding: Hardcover
• Edition number: 1
• Number of pages: 921