Tracer Kinetics in Biomedical Research: From Data to Model

0 avg rating
( 0 ratings by Goodreads )
 
9780306464270: Tracer Kinetics in Biomedical Research: From Data to Model

The use of mathematical modeling techniques in biomedical research is playing an increasingly important role in the understanding of the pathophysiology of disease processes. This includes not only understanding mechanisms of physiological processes, but also diagnosis and treatment. In addition, its introduction in the study of genomics and proteomics is key in understanding the functional characteristics of gene expression and protein assembly and secretion. Finally, with the increasing complexity and associated cost of drug development, modeling techniques are being used to streamline the process. This book is designed to give the reader the mathematical and statistical information necessary to design tracer kinetic studies, to use noncompartmental methodologies and/or to develop multicompartmental models to interpret the data.
The book starts with a review of fundamentals of radioactive and stable isotope tracer kinetics and then proceeds with a description of the noncompartmental and multicompartmental modeling methodologies to study systems in the steady state. The focus is on understanding the basic assumptions inherent in the methodologies and the underlying mathematics and statistics, on discussing how to assess how `good' a model is and on giving some hints on how better to design kinetic studies, in order to increase the probability of a successful study and to ensure the maximal information content in the experimental data to be extracted. The book has an extensive section on parameter estimation, i.e., fitting models to data, first in general terms and then specifically related to noncompartmental and compartmental models. This is written from a basic point of view, and is intended to remove the mystery from the `black box' of computer optimization software. Finally, a special application often found in tracer kinetic analysis, precursor-product relationships, is discussed.
Throughout the book, the goal is to provide even the novice with sufficient background so that he/she can feel comfortable. A number of case studies, based upon real experimental data, are carried through the text. Other examples illustrate specific points. All data examples are provided on a floppy disk.

"synopsis" may belong to another edition of this title.

Buy New View Book
List Price: US$ 249.00
US$ 229.17

Convert Currency

Shipping: US$ 5.10
From United Kingdom to U.S.A.

Destination, Rates & Speeds

Add to Basket

Top Search Results from the AbeBooks Marketplace

1.

Cobelli, Claudio
Published by Springer (2016)
ISBN 10: 0306464276 ISBN 13: 9780306464270
New Paperback Quantity Available: 1
Print on Demand
Seller:
Ria Christie Collections
(Uxbridge, United Kingdom)
Rating
[?]

Book Description Springer, 2016. Paperback. Book Condition: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Bookseller Inventory # ria9780306464270_lsuk

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 229.17
Convert Currency

Add to Basket

Shipping: US$ 5.10
From United Kingdom to U.S.A.
Destination, Rates & Speeds

2.

Claudio Cobelli
Published by Springer Science+Business Media (2001)
ISBN 10: 0306464276 ISBN 13: 9780306464270
New Quantity Available: > 20
Print on Demand
Seller:
Books2Anywhere
(Fairford, GLOS, United Kingdom)
Rating
[?]

Book Description Springer Science+Business Media, 2001. HRD. Book Condition: New. New Book. Delivered from our US warehouse in 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND.Established seller since 2000. Bookseller Inventory # IP-9780306464270

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 236.10
Convert Currency

Add to Basket

Shipping: US$ 11.88
From United Kingdom to U.S.A.
Destination, Rates & Speeds

3.

CLAUDIO COBELLI
Published by Springer (2001)
ISBN 10: 0306464276 ISBN 13: 9780306464270
New Hardcover Quantity Available: 1
Seller:
Herb Tandree Philosophy Books
(Stroud, GLOS, United Kingdom)
Rating
[?]

Book Description Springer, 2001. Hardback. Book Condition: NEW. 9780306464270 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. Bookseller Inventory # HTANDREE0270727

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 243.60
Convert Currency

Add to Basket

Shipping: US$ 10.55
From United Kingdom to U.S.A.
Destination, Rates & Speeds

4.

Claudio Cobelli
Published by Springer Science+Business Media (2001)
ISBN 10: 0306464276 ISBN 13: 9780306464270
New Quantity Available: > 20
Print on Demand
Seller:
Pbshop
(Wood Dale, IL, U.S.A.)
Rating
[?]

Book Description Springer Science+Business Media, 2001. HRD. Book Condition: New. New Book.Shipped from US within 10 to 14 business days.THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Bookseller Inventory # IP-9780306464270

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 260.19
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds

5.

Cobelli, Claudio
Published by Springer (2017)
ISBN 10: 0306464276 ISBN 13: 9780306464270
New Hardcover Quantity Available: > 20
Print on Demand
Seller:
Murray Media
(North Miami Beach, FL, U.S.A.)
Rating
[?]

Book Description Springer, 2017. Hardcover. Book Condition: New. Never used! This item is printed on demand. Bookseller Inventory # 0306464276

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 265.82
Convert Currency

Add to Basket

Shipping: US$ 1.99
Within U.S.A.
Destination, Rates & Speeds

6.

Claudio Cobelli, David Foster, Gianna Toffolo
Published by Springer Science+Business Media, United States (2001)
ISBN 10: 0306464276 ISBN 13: 9780306464270
New Hardcover Quantity Available: 10
Print on Demand
Seller:
The Book Depository US
(London, United Kingdom)
Rating
[?]

Book Description Springer Science+Business Media, United States, 2001. Hardback. Book Condition: New. 2002 ed.. Language: English . Brand New Book ***** Print on Demand *****. The use of mathematical modeling te chniques in biomedical research is playing an increasingly important role aso ne seeks tounderstand the physiopathology of disease processes. This includes not only understand ing mechanisms ofphysiological processes, but diagnosis and treatment. In addition, its introduction in the study of genomics andproteomics is key in understanding the functional ch aracteristics of gene expression and protein assembly and secretion. Finally, with the increasing com plexity and associated cost of drug development, modeling techniques are being used to streamline the process. We have workedin c lose collaboration with colleagues in biomedical and pharmaceutical research for a number of years applying and refining mathematical modeling techniques to avariety o f problems. In addition, we haveworked incollaboration with colleagues in applied m athematics and statistics to develop new algorithms to solve new setsof problems as theyemerge ino ur research efforts. Finally, we have worked with colleagues in computer sciencet o develop new software tools that bring the power of mathematical modeling to a broad research community. This books brings together mucho f what we have learned over the years, and presents the material in a format that should be accessible both to the novice reader and those desiring more detailed information about specific techniques. Bookseller Inventory # APC9780306464270

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 273.83
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

7.

Claudio Cobelli, David Foster, Gianna Toffolo
Published by Springer Science+Business Media, United States (2001)
ISBN 10: 0306464276 ISBN 13: 9780306464270
New Hardcover Quantity Available: 10
Print on Demand
Seller:
The Book Depository
(London, United Kingdom)
Rating
[?]

Book Description Springer Science+Business Media, United States, 2001. Hardback. Book Condition: New. 2002 ed.. Language: English . Brand New Book ***** Print on Demand *****.The use of mathematical modeling te chniques in biomedical research is playing an increasingly important role aso ne seeks tounderstand the physiopathology of disease processes. This includes not only understand ing mechanisms ofphysiological processes, but diagnosis and treatment. In addition, its introduction in the study of genomics andproteomics is key in understanding the functional ch aracteristics of gene expression and protein assembly and secretion. Finally, with the increasing com plexity and associated cost of drug development, modeling techniques are being used to streamline the process. We have workedin c lose collaboration with colleagues in biomedical and pharmaceutical research for a number of years applying and refining mathematical modeling techniques to avariety o f problems. In addition, we haveworked incollaboration with colleagues in applied m athematics and statistics to develop new algorithms to solve new setsof problems as theyemerge ino ur research efforts. Finally, we have worked with colleagues in computer sciencet o develop new software tools that bring the power of mathematical modeling to a broad research community. This books brings together mucho f what we have learned over the years, and presents the material in a format that should be accessible both to the novice reader and those desiring more detailed information about specific techniques. Bookseller Inventory # APC9780306464270

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 280.37
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

8.

Claudio Cobelli; David Foster; Gianna Toffolo
ISBN 10: 0306464276 ISBN 13: 9780306464270
New Quantity Available: 5
Seller:
ReadWhiz
(Portland, OR, U.S.A.)
Rating
[?]

Book Description Book Condition: New. Bookseller Inventory # ria9780306464270_ing

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 285.13
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

9.

Cobelli, Claudio, Foster, David, Toffolo
Published by Springer (2017)
ISBN 10: 0306464276 ISBN 13: 9780306464270
New Hardcover Quantity Available: 2
Print on Demand
Seller:
Murray Media
(North Miami Beach, FL, U.S.A.)
Rating
[?]

Book Description Springer, 2017. Hardcover. Book Condition: New. Never used! This item is printed on demand. Bookseller Inventory # P110306464276

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 292.40
Convert Currency

Add to Basket

Shipping: US$ 1.99
Within U.S.A.
Destination, Rates & Speeds

10.

Claudio Cobelli, David Foster, Gianna Toffolo
Published by Springer (2001)
ISBN 10: 0306464276 ISBN 13: 9780306464270
New Hardcover Quantity Available: 1
Print on Demand
Seller:
Ergodebooks
(RICHMOND, TX, U.S.A.)
Rating
[?]

Book Description Springer, 2001. Hardcover. Book Condition: New. 2001. This item is printed on demand. Bookseller Inventory # DADAX0306464276

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 311.81
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds

There are more copies of this book

View all search results for this book