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Synopsis
The use of mathematical modeling te chniques in biomedical research is playing an increasingly important role aso ne seeks tounderstand the physiopathology of disease processes. This includes not only understand ing mechanisms ofphysiological processes, but diagnosis and treatment. In addition, its introduction in the study of genomics andproteomics is key in understanding the functional ch aracteristics of gene expression and protein assembly and secretion. Finally, with the increasing com plexity and associated cost of drug development, modeling techniques are being used to streamline the process. We have workedin c lose collaboration with colleagues in biomedical and pharmaceutical research for a number of years applying and refining mathematical modeling techniques to avariety o f problems. In addition, we haveworked incollaboration with colleagues in applied m athematics and statistics to develop new algorithms to solve new setsof problems as theyemerge ino ur research efforts. Finally, we have worked with colleagues in computer sciencet o develop new software tools that bring the power of mathematical modeling to a broad research community. This books brings together mucho f what we have learned over the years, and presents the material in a format that should be accessible both to the novice reader and those desiring more detailed information about specific techniques.
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Tracer Kinetics in Biomedical Research: from Data to Model
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gebundene Ausgabe. Condition: Gut. 456 Seiten Das hier angebotene Buch stammt aus einer teilaufgelösten wissenschaftlichen Bibliothek und trägt die entsprechenden Kennzeichnungen (Rückenschild, Instituts-Stempel.); der Buchzustand ist ansonsten ordentlich und dem Alter entsprechend gut. Sprache: Englisch Gewicht in Gramm: 900. Seller Inventory # 1296613
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Tracer Kinetics in Biomedical Research : From Data to Model
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Tracer Kinetics in Biomedical Research (Hardcover)
Published by
Springer Science+Business Media, New York, 2001
ISBN 10: 0306464276
ISBN 13: 9780306464270
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Hardcover. Condition: new. Hardcover. The use of mathematical modelling techniques in biomedical research is playing an increasingly important role in the understanding of the pathophysiology of disease processes. This includes not only understanding mechanisms of physiological processes, but also diagnosis and treatment. In addition, its introduction in the study of genomics and proteomics is key in understanding the functional characteristics of gene expression and protein assembly and secretion. Finally, with the increasing complexity and associated cost of drug development, modelling techniques are being used to streamline the process. This book is designed to give the reader the mathematical and statistical information necessary to design tracer kinetic studies, to use non-compartmental methodologies and/or to develop multi-compartmental models to interpret the data. The book starts with a review of fundamentals of radioactive and stable isotope tracer kinetics and then proceeds with a description of the non-compartmental and multi-compartmental modelling methodologies to study systems in the steady state.The focus is on understanding the basic assumptions inherent in the methodologies and the underlying mathematics and statistics, on discussing how to assess how "good" a model is and on giving some hints on how better to design kinetic studies, in order to increase the probability of a successful study and to ensure the maximal information content in the experimental data to be extracted. The book has a section on parameter estimation, fitting models to data, first in general terms and then specifically related to non-compartmental and compartmental models. This is written from a basic point of view, and is intended to remove the mystery from the "black box" of computer optimization software. Finally, a special application often found in tracer kinetic analysis, precursor-product relationships, is discussed. Throughout the book, the goal is to provide even the novice with sufficient background so that he/she can feel comfortable. A number of case studies, based upon real experimental data, are carried through the text. Other examples illustrate specific points. All data examples are provided on a floppy disk. The use of mathematical modeling techniques in biomedical research is playing an increasingly important role in the understanding of the pathophysiology of disease processes. This book offers the mathematical and statistical information necessary to design tracer kinetic studies. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. Seller Inventory # 9780306464270
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Tracer Kinetics in Biomedical Research: From Data to Model
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Tracer Kinetics in Biomedical Research: From Data to Model
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Tracer Kinetics in Biomedical Research: From Data to Model
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Condition: New. 1. Introduction. 2. Fundamentals of Tracer Kinetics. 3. The Noncompartmental Model of Multipool Systems. 4. The Compartmental Model. 5. Identifiability of the Tracer Model. 6. Using the Tracer Model to Estimate Kinetic Parameters. 7. Compartmental Versu. Seller Inventory # 458417937
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Tracer Kinetics in Biomedical Research : From Data to Model
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Buch. Condition: Neu. Neuware - The use of mathematical modeling te chniques in biomedical research is playing an increasingly important role aso ne seeks tounderstand the physiopathology of disease processes. This includes not only understand ing mechanisms ofphysiological processes, but diagnosis and treatment. In addition, its introduction in the study of genomics andproteomics is key in understanding the functional ch aracteristics of gene expression and protein assembly and secretion. Finally, with the increasing com plexity and associated cost of drug development, modeling techniques are being used to streamline the process. We have workedin c lose collaboration with colleagues in biomedical and pharmaceutical research for a number of years applying and refining mathematical modeling techniques to avariety o f problems. In addition, we haveworked incollaboration with colleagues in applied m athematics and statistics to develop new algorithms to solve new setsof problems as theyemerge ino ur research efforts. Finally, we have worked with colleagues in computer sciencet o develop new software tools that bring the power of mathematical modeling to a broad research community. This books brings together mucho f what we have learned over the years, and presents the material in a format that should be accessible both to the novice reader and those desiring more detailed information about specific techniques. Seller Inventory # 9780306464270
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Tracer Kinetics in Biomedical Research (Hardcover)
Published by
Springer Science+Business Media, New York, 2001
ISBN 10: 0306464276
ISBN 13: 9780306464270
New
Hardcover
Seller: AussieBookSeller, Truganina, VIC, Australia
Seller rating 5 out of 5 stars
Hardcover. Condition: new. Hardcover. The use of mathematical modelling techniques in biomedical research is playing an increasingly important role in the understanding of the pathophysiology of disease processes. This includes not only understanding mechanisms of physiological processes, but also diagnosis and treatment. In addition, its introduction in the study of genomics and proteomics is key in understanding the functional characteristics of gene expression and protein assembly and secretion. Finally, with the increasing complexity and associated cost of drug development, modelling techniques are being used to streamline the process. This book is designed to give the reader the mathematical and statistical information necessary to design tracer kinetic studies, to use non-compartmental methodologies and/or to develop multi-compartmental models to interpret the data. The book starts with a review of fundamentals of radioactive and stable isotope tracer kinetics and then proceeds with a description of the non-compartmental and multi-compartmental modelling methodologies to study systems in the steady state.The focus is on understanding the basic assumptions inherent in the methodologies and the underlying mathematics and statistics, on discussing how to assess how "good" a model is and on giving some hints on how better to design kinetic studies, in order to increase the probability of a successful study and to ensure the maximal information content in the experimental data to be extracted. The book has a section on parameter estimation, fitting models to data, first in general terms and then specifically related to non-compartmental and compartmental models. This is written from a basic point of view, and is intended to remove the mystery from the "black box" of computer optimization software. Finally, a special application often found in tracer kinetic analysis, precursor-product relationships, is discussed. Throughout the book, the goal is to provide even the novice with sufficient background so that he/she can feel comfortable. A number of case studies, based upon real experimental data, are carried through the text. Other examples illustrate specific points. All data examples are provided on a floppy disk. The use of mathematical modeling techniques in biomedical research is playing an increasingly important role in the understanding of the pathophysiology of disease processes. This book offers the mathematical and statistical information necessary to design tracer kinetic studies. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. Seller Inventory # 9780306464270
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