This textbook on applied probability is intended for graduate students in applied mathematics, biostatistics, computational biology, computer science, physics, and statistics. It presupposes knowledge of multivariate calculus, linear algebra, ordinary differential equations, and elementary probability theory. Given these prerequisites, Applied Probability presents a unique blend of theory and applications, with special emphasis on mathematical modeling, computational techniques, and examples from the biological sciences. Chapter 1 reviews elementary probability and provides a brief survey of relevant results from measure theory. Chapter 2 is an extended essay on calculating expectations. Chapter 3 deals with probabilistic applications of convexity, inequalities, and optimization theory. Chapters 4 and 5 touch on combinatorics and combinatorial optimization. Chapters 6 through 11 present core material on stochastic processes. If supplemented with appropriate sections from Chapters 1 and 2, there is sufficient material here for a traditional semester-long course in stochastic processes covering the basics of Poisson processes, Markov chains, branching processes, martingales, and diffusion processes. Finally, Chapters 12 and 13 develop the Chen-Stein method of Poisson approximation and connections between probability and number theory. Kenneth Lange is Professor of Biomathematics and Human Genetics and Chair of the Department of Human Genetics at the UCLA School of Medicine. He has held appointments at the University of New Hampshire, MIT, Harvard, and the University of Michigan. While at the University of Michigan, he was the Pharmacia & Upjohn Foundation Professor of Biostatistics. His research interests include human genetics, population modeling, biomedical imaging, computational statistics, and applied stochastic processes. Springer-Verlag published his books Numerical Analysis for Statisticians and Mathematical and Statistical Methods for Genetic Analysis Second Edition, in 1999 and 2002, respectively.
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Applied Probability presents a unique blend of theory and applications, with special emphasis on mathematical modeling, computational techniques, and examples from the biological sciences. It can serve as a textbook for graduate students in applied mathematics, biostatistics, computational biology, computer science, physics, and statistics. Readers should have a working knowledge of multivariate calculus, linear algebra, ordinary differential equations, and elementary probability theory. Chapter 1 reviews elementary probability and provides a brief survey of relevant results from measure theory. Chapter 2 is an extended essay on calculating expectations. Chapter 3 deals with probabilistic applications of convexity, inequalities, and optimization theory. Chapters 4 and 5 touch on combinatorics and combinatorial optimization. Chapters 6 through 11 present core material on stochastic processes. If supplemented with appropriate sections from Chapters 1 and 2, there is sufficient material for a traditional semester-long course in stochastic processes covering the basics of Poisson processes, Markov chains, branching processes, martingales, and diffusion processes. The second edition adds two new chapters on asymptotic and numerical methods and an appendix that separates some of the more delicate mathematical theory from the steady flow of examples in the main text. Besides the two new chapters, the second edition includes a more extensive list of exercises, many additions to the exposition of combinatorics, new material on rates of convergence to equilibrium in reversible Markov chains, a discussion of basic reproduction numbers in population modeling, and better coverage of Brownian motion. Because many chapters are nearly self-contained, mathematical scientists from a variety of backgrounds will find Applied Probability useful as a reference. Kenneth Lange is the Rosenfeld Professor of Computational Genetics in the Departments of Biomathematics and Human Genetics at the UCLA School of Medicine and the Chair of the Department of Human Genetics. His research interests include human genetics, population modeling, biomedical imaging, computational statistics, high-dimensional optimization, and applied stochastic processes. Springer previously published his books Mathematical and Statistical Methods for Genetic Analysis, 2nd ed., Numerical Analysis for Statisticians, 2nd ed., and Optimization. He has written over 200 research papers and produced with his UCLA colleague Eric Sobel the computer program Mendel, widely used in statistical genetics.
Kenneth Lange is the Rosenfeld Professor of Computational Genetics, and a faculty member in the Departments of Biomathematics, Human Genetics and Statistics, at the University of California, Los Angeles. He has held appointments at the University of New Hampshire, Massachusetts Institute of Technology, Harvard University, the University of Michigan, the University of Helsinki and Stanford University. He is a Fellow of the American Statistical Association, the Institute of Mathematical Statistics, and the American Institute for Medical and Biomedical Engineering. He won the Snedecor Award from the Joint Statistical Societies in 1993 and gave a platform presentation at the 2015 International Congress of Mathematicians. His research interests include human genetics, population modeling, biomedical imaging, computational statistics, optimization theory, and applied stochastic processes. He has published four previous books: Mathematical and Statistical Methods for Genetic Analysis, Numerical Analysis for Statisticians, Applied Probability, and Optimization, all in second editions.
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