Bioinformatics and Computational Biology Solutions Using R and Bioconductor (Encyclopaedia of Mathematical Sciences) - Softcover

Softcover

ISBN 10: 0387505830 ISBN 13: 9780387505831

Publisher: Springer, 2008

Synopsis

The theory of singularities is an important part of various branches of mathematics: algebraic geometry, differential topology, geometric optics, etc. Here the focus is on the singularities of smooth maps and applications to dynamical systems - in particular, bifurcations. This includes the study of bifurcations of intersections of stable and unstable cycles. Along with the formal algebraic and analytic aspects of the theory, the authors consider global topological problems related to invariants. The authors have in mind a student reader, mathematician, or physicist, who wishes to learn the modern techniques of local mathematical analysis as an instrument for applied studies or a specialist in one of the applied areas who is looking for the necessary mathematical tools.

About this title

From the Back Cover

Bioconductor is a widely used open source and open development software project for the analysis and comprehension of data arising from high-throughput experimentation in genomics and molecular biology. Bioconductor is rooted in the open source statistical computing environment R. This volume's coverage is broad and ranges across most of the key capabilities of the Bioconductor project, including

importation and preprocessing of high-throughput data from microarray, proteomic, and flow cytometry platforms

curation and delivery of biological metadata for use in statistical modeling and interpretation

statistical analysis of high-throughput data, including machine learning and visualization,

modeling and visualization of graphs and networks.

The developers of the software, who are in many cases leading academic researchers, jointly authored chapters. All methods are illustrated with publicly available data, and a major section of the book is devoted to exposition of fully worked case studies.

This book is more than a static collection of descriptive text, figures, and code examples that were run by the authors to produce the text; it is a dynamic document. Code underlying all of the computations that are shown is made available on a companion website, and readers can reproduce every number, figure, and table on their own computers.

Robert Gentleman is Head of the Program in Computational Biology at the Fred Hutchinson Cancer Research Center in Seattle. He is one of the two authors of the original R system and a leading member of the R core team. Vincent Carey is Associate Professor of Medicine (Biostatistics), Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School. Gentleman and Carey are co-founders of the Bioconductor project. Wolfgang Huber is Group Leader in the European Molecular Biology Laboratory at the European Bioinformatics Institute in Cambridge. He has made influential contributions to the error modeling of microarray data. Rafael Irizarry is Associate Professor of Biostatistics at the Johns Hopkins Bloomberg School of Public Health in Baltimore. He is co-developer of RMA and GCRMA, two of the most popular methodologies for preprocessing high-density oligonucleotide arrays. Sandrine Dudoit is Assistant Professor in the Department of Biostatistics at the University of California, Berkeley. She has made seminal discoveries in the fields of multiple testing and generalized cross-validation and spearheaded the deployment of these findings in applied genomic science.

Review

From the reviews:

"The book has several nice touches that readers will appreciate. First, the liberal use of color shows the full capabilities of Bioconductor pakages and brings the material to life. Second, color figures are dispersed throughout the text rather than being relegated to a central section of color plates. Third, the index indicates whether a term references a package, function or class. This book is an excellent resource... In summary, this book is a must have for any Bioconductor user." (J. Wade Davis, Journal of the American Statistical Association, Vol. 102, No. 477, 2007)

"This book is solid evidence of the influence that quantitative researchers can have on biological investigations. Organized into separate chapters of shared authorship, the book provides a valuable overview of the impact that the authors and their colleagues have had on the analysis of genomic data." (R.W. Doerge, Biostatistics, December 2006)

"This book provides an in-depth demonstration of the potential of the Bioconductor project, through a varied mixture of descriptions, figures and examples. ... The book ... is an exciting opportunity for researchers to learn directly from the software developers themselves. The range of material covered by the book is diverse and well structured. An abundance of fully worked case studies illustrate the methods in practice. ... it should be a must for any researcher considering getting started with the software ... ." (Rebecca Walls, Journal of Applied Statistics, Vol. 34 (3), 2007)

"The book provides an extensive overview over the most important tasks in analyzing genomic data with Bioconductor. ... The book is well written and communicates hands-on experience of the developers of the respective Bioconductor packages themselves. ... The book is targeted to a broad range of researchers interested in genomic data analysis, including biologists, bioinformaticians, and statisticians. ... It is a very valuable resource for modern genomic data analysis. There is no comparable book on the market." (Jörg Rahnenführer, Statistical Papers, Vol. 50, 2009)

Edition details

• Publisher: Springer
• Publication date: 2008
• Language: English
• ISBN 10: 0387505830
• ISBN 13: 9780387505831
• Binding: Paperback
• Number of pages: 500
• Editor: Gentleman Robert, Carey Vincent, Huber Wolfgang