Synopsis
Table of Contents Foreword Marshall Nirenberg Preface John F. Atkins, Raymond F. Gesteland Selenocysteine Biosynthesis, Selenoproteins and Selenoproteomes Vadim N. Gladyshev, Dolph L. Hatfield Reprogramming the Ribosome for Selenoprotein Expression: RNA Elements and Protein Factors Marla J. Berry, Michael T. Howard Translation of UAG as pyrrolysine Joseph A. Krzycki Specification of standard amino acids by stop codons Olivier Namy, Jean-Pierre Rousset Ribosome 'Skipping': 'Stop-Carry On' or 'StopGo' Translation Jeremy D. Brown, Martin D. Ryan Recoding Therapies for Genetic Diseases Kim M. Keeling, David M. Bedwell Pseudoknot-dependent Programmed -1 Ribosomal Frameshifting: Structures, Mechanisms and Models Ian Brierley, Robert J. C. Gilbert, Simon Pennell Programmed -1 ribosomal frameshift in the human immunodeficiency virus of type 1 Léa Brakier-Gingras, Dominic Dulude Ribosomal frameshifting in decoding plant viral RNAs W. Allen Miller, David P. Giedroc Programmed frameshifting in budding yeast Philip J. Farabaugh Recoding in bacteriophages Roger W. Hendrix Programmed Ribosomal -1 Frameshifting as a Tradition: the Bacterial Transposable Elements of the IS3 Family Olivier Fayet, Marie-Françoise Prère Autoregulatory frameshifting in antizyme gene expression governs polyamine levels from yeast to mammals Ivaylo P. Ivanov, Senya Matsufuji Sequences promoting Recoding are Singular Genomic Elements Pavel V.Baranov, Olga Gurvich Mutants that affect recoding Jonathon D. Dinman, Michael O'Connor The E site and its importance for improving accuracy and preventing frameshifts Markus Pech, Oliver Vesper, Hiroshi Yamamoto, Daniel N. Wilson, Knud H. Nierhaus Translational Bypassing - peptidyl-tRNA re-paring at non-overlapping sites Norma M. Wills trans-Translation Kenneth Keiler, Dennis M. Lee Transcript slippage and recoding Michael Anikin, Vadim Molodtsov, Dmitry Temiakov, William T. McAllister Computational resources for studying recoding Andrew E. Firth, Michaël Bekaert, Pavel V. Baranov Appendix
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From the Back Cover
The dynamic nature of decoding the information in messenger RNA was unanticipated at the time the genetic code was first deciphered. We now know that both the meaning of individual codons and the framing of the readout process can be modified by information in specific messenger RNAs. This book describes this "Recoding" phenomenon, revealing the diversity of an additional layer of information in mRNAs that serves to enrich the expression of genes. Knowledge of recoding is essential for understanding the organization and expression of genes in viruses and all organisms ranging from bacteria to archeae to plants to humans, making Recoding pertinent to all biological sciences.
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