Principles of Nucleic Acid Structure (Springer Advanced Texts in Chemistry) - Softcover

Saenger, Wolfram

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9780387907611: Principles of Nucleic Acid Structure (Springer Advanced Texts in Chemistry)

Softcover

ISBN 10: 0387907610 ISBN 13: 9780387907611

Publisher: Springer, 1983

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New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical ther� modynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the grad� uate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses. CHARLES R. CANTOR New York Preface This monograph is based on a review on polynucleotide structures written for a book series in 1976.

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From the Reviews of the First Edition: "From time to time one reads a book or an account of an experiment and wishes, with more pleasure than envy, that one had produced it oneself. Wolfram Saenger's book is such a virtuoso production: well written, profusely illustrated and astonishingly comprehensive. In it, fact and hypothesis are distinguished with rare scrupulousness. Any serious student or researcher will find it a mine of information. The merely curious now have a guidebook with which safely to explore the labyrinth of DNA and RNA structural studies. Particularly praiseworthy is the way Saenger has managed to deal thoroughly but interestingly with all the fundamental business of conformational nomenclature and crystallographic esoterica. He has not failed to explore the many structural hypotheses still twisting slowly in the wind, but almost nowhere does he confuse these with experimentally well-founded models. ...Current X-ray structural studies focus on oligonucleotides in single crystals and in poly(oligonucleotides) in fibres. These structures are less regular. Whether or not the excursions from regularity are related to base sequences is a lively issue. More ambitiously - and perhaps more wisely - there are increasingly successful studies of DNA bound to histones and other proteins which will reveal specifically how variety and variability in the genetic material can be exploited biologically. Among all its other riches, Saenger's book makes us aware of these too." Nature#1

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