Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins (Methods of Biochemical Analysis) - Softcover

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9780471191964: Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins (Methods of Biochemical Analysis)

Softcover

ISBN 10: 0471191965 ISBN 13: 9780471191964

Publisher: Wiley-Interscience, 1998

"A reference that should be in the personal library of any biologist who uses the Internet for the analysis of DNA and protein sequence data" --Science

"synopsis" may belong to another edition of this title.

From the Publisher:

As the Human Genome Project continues to generate raw sequence information, the most successful scientists will be those who can provide a biological interpretation of that data. This practical guide helps the molecular biologist design and implement a successful sequence analysis strategy, utilizing the overwhelming array of tools available, including Internet resources.

From the Inside Flap:

Bioinformatics A Practical Guide to the Analysis of Genes and Proteins Edited by Andreas D. Baxevanis and B. F. Francis Ouellette With the explosion of sequence and structural information available to researchers, the field of bioinformatics is playing an increasingly large role in the study of fundamental biological problems. The challenge facing biologists, especially in light of the vast amount of data being produced by the Human Genome Project and other systematic sequencing efforts, will be the effective utilization of sequence-based information on two fronts: first, to reveal previously unknown relationships—ranging from the identification of unknown genes to the prediction of protein structures; and, second, to use predictions and inferences made from these data to better design experiments in the laboratory as genome projects move from the realm of structural genomics into one of functional genomics. Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins makes computational biology accessible to scientists at all levels of expertise, including those with no formal computer training, by taking an example-driven approach accompanied by a large number of illustrations. By focusing in on a selected group of powerful methods, the book cuts through the overwhelming array of existing tools and databases, helping the reader quickly design and implement a successful sequence analysis strategy. Presented by leading authorities in computational biology, this edited volume covers a broad range of topics in bioinformatics, beginning with a gentle reintroduction to the use of software and Internet resources and culminating with a discussion of how readers can submit their own sequence data to the public databases. Other topics covered in this volume include:

The GenBank sequence database
Structural databases and basic tools for viewing three-dimensional structures
Sequence analysis using the integrated GCG package
Information retrieval from biological databases
The NCBI data model
Effective methodologies for performing sequence-based database searches
Practical aspects of multiple sequence alignment
Phylogenetic analysis
Predictive methods using protein and nucleotide sequences
Navigating public physical mapping databases
The AceDB database for organizing and presenting genome information

Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins is fully referenced and provides appendices, a glossary, sample sequence file formats, and over 120 illustrations. This volume is a must have for molecular biologists, geneticists, biochemists, and any other biologist interested in using sequence information to advantage in the laboratory. The topics have been arranged to build upon one another so that the book can also be used in a one-semester practical course on sequence analysis and bioinformatics.