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Translational Stroke Research: From Target Selection to Clinical Trials is part of “Springer Series in Translational Stroke Research.” Forty-three chapters from leading stroke research groups around the world select future targets and methods for stroke management such as the vasculature and white matter, protein aggregation, neuroglobin, microRNAs, oxidation, soluble epoxide hydrolase, apoptosis, hypoxia-inducible factors, thrombin, toll-like receptor, angiogenesis, membrane potentials and pumps. The book discusses methods to regulate brain temperature and the use of preconditioning in stroke. It also presents new areas of research emphasizing restoration of function with growth factors and stem cells. It provides multiple animal models of both ischemic and hemorrhagic stroke in order to translate basic preclinical findings to clinical trials with de-risking issues, therapy delivery methods such as sustained-release and intranasal delivery, and potential therapies including cell therapies, albumin, transcranial laser, microbubbles, and ultrasound. Finally, it debates clinical trial design for analytical methodology, imaging, computation, and innovations.
From the reviews:
“This book is an excellent review of cerebral hemorrhage, ischemia, and hypoxia as it involves pathology, pathophysiology, and cellular tolerance. It will appeal to a wide variety of investigators in stroke, neurology, and neurosurgery research. I highly recommend it in Neurology Research.” (Joseph J. Grenier, Amazon.com, February, 2014)
“In Translational Stroke Research, Lapchak and Zhang have gathered an impressive, and very large, assortment of clinicians and researchers from around the world to offer reports of their studies, new ideas ... and directions for future research based mainly on pleotropic and combined therapies. ... The authors are to be congratulated on a great effort in furthering the available information and pitfalls in this field and pointing researchers and practitioners in a clinically significant direction. ... It makes for fascinating reading!” (Elizabeth A. M. Frost, Journal of Neurosurgical Anesthesiology, Vol. 24 (4), October, 2012)"About this title" may belong to another edition of this title.
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Book Description Gebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Sets a basis for effective translational research Emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assaysEach chapter specifically addresses one or more components of preclinical s. Seller Inventory # 4176711
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Book Description Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The purpose of the volume will be to set a basis for effective translational research. By inviting experts in the field of translational stroke research, each chapter will specifically address one or more components of preclinical stroke research. The emphasis will be placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design. 948 pp. Englisch. Seller Inventory # 9781441995292
Book Description Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - The purpose of the volume will be to set a basis for effective translational research. By inviting experts in the field of translational stroke research, each chapter will specifically address one or more components of preclinical stroke research. The emphasis will be placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design. Seller Inventory # 9781441995292