Myocardial Ischemia: Proceedings of a Satellite Symposium of the Thirtieth International Physiological Congress July 8–11, 1986, Winnipeg, Canada (Developments in Cardiovascular Medicine) - Softcover

Softcover

ISBN 10: 1461292212 ISBN 13: 9781461292210

Publisher: Springer, 2013

Synopsis

Whenever the coronary flow is inadequate to provide enough oxygen to meet the energy demands of the tissue, the heart becomes ischemic. Manifestations of myocardial ischemia include depression in contractile activity, changes in metabolic pattern, abnormalities in ultrastructure, and alterations in membrane potential. Ischemic changes during the early phase are reversible but as the period of ischemia is extended, the injury becomes irreversible. The transition from reversible to irreversible ischemic injury is usually associated with some membrane defects. It is worthwhile to consider that the irreversible damage to the ischemic myocardium occurs when the sarcolemmal membrane is altered in suoh a way that it would promote 2 a net gain of ca + in the cardiac cell upon reinstitution of blood flow. Suoh a lesion could result when mechanisms for the entry as well as removal 2 of ca + from the myocardial oell become defective. In this regard, 2 depression of the sarcolemmal ca + pump would favour the oocurrenoe of 2 intracellular ca + overload. Furthermore, inhibition of the Na+-K+ pump would lead to elevation of myoplasmic Na+ which oould then increase the 2 2 intracellular concentration of ca + through the sarcolemmal Na+-ca + exchange mechanism. In faot recent studies have revealed an inhibition of 2 the sarcolemmal Na+-ca + exchange mechanism in the ischemic heart and this 2 change could also contribute towards the occurrence of intracellular ca + 2 overload.

Edition details

• Publisher: Springer
• Publication date: 2013
• Language: English
• ISBN 10: 1461292212
• ISBN 13: 9781461292210
• Binding: Paperback
• Number of pages: 367
• Editor: Dhalla Naranjan S., Innes Ian R., Beamish Robert E.