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Heat Shock Proteins and Cytoprotection: Atp-Deprived Mammalian Cells (Molecular Biology Intelligence Unit) - Softcover
Synopsis
This book considers a recently discovered function of heat shock proteins (HSP): adaptation of mammalian cells to energy deficiency. It discusses the following main problems: 1) how do cells sense transient ATP decrease and why does it evoke heat shock response?; 2) how can HSPs protect cells from damage and death and what are their intracellular targets?; 3) what may be a clinical application of HSP-mediated adaptation to ischemia?
"synopsis" may belong to another edition of this title.
- PublisherSpringer
- Publication date2012
- ISBN 10 1461377528
- ISBN 13 9781461377528
- BindingPaperback
- LanguageEnglish
- Number of pages253
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Heat Shock Proteins and Cytoprotection: Atp-Deprived Mammalian Cells (Molecular Biology Intelligence Unit)
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Heat Shock Proteins and Cytoprotection
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -1. Heat Shock Proteins and the Regulation of Heat Shock Gene Expression in Eukaryotes.- 1.1. The Family of Stress Proteins and Molecular Chaperones.- 1.2. The Regulation of Heat Shock Gene Expression in Eukaryotes.- Concluding Remarks.- 2. ATP Homeostasis, Ionic Balance and Cell Viability.- 2.1. ATP Homeostasis in Mammalian Cells.- 2.2. Cell Viability and ATP Depletion.- 2.3. Significance of Ionic Imbalance for the Death of ATP-Depleted Cells.- 2.4. Mitochondrial Dysfunction and Damage During Ischemia.- Concluding Remarks.- 3. ¿Proteotoxicity¿ of ATP Depletion: Disruption of the Cytoskeleton, Protein Aggregation and Involvement of Molecular Chaperones.- 3.1. The Cytoskeleton Under ATP Deprivation.- 3.2. Protein Aggregation in Energy-Deprived Cells.- 3.3. How Do Heat Shock Proteins Respond to ATP Depletion .- Concluding Remarks.- 4. ATP Depletion as Inducer of Heat Shock Protein Expression.- 4.1. Anoxia and Mitochondrial Inhibitors Activate HSP Gene Expression.- 4.2. Ischemia-Induced HSP Synthesis in the Heart.- 4.3. Stress Protein Expression in Post-Ischemic Brain.- 4.4. Ischemia-Induced Stress Protein Synthesis in Other Normal Tissues and Tumor Cells.- 4.5. Possible Mechanisms of HSP Accumulation After ATP Depletion.- Concluding Remarks.- 5. Heat Shock Proteins and Cardioresistance to Ischemia.- 5.1. Heat Shock-Induced Cardioresistance to Ischemia/Reperfusion Injury.- 5.2. The Role of Myocardial HSPs in Ischemie Preconditioning.- 5.3. The Cardioresistance Induced by Other Stimuli Can Also Be Associated with HSPs.- 5.4. Evidence for the Involvement of HSP70 in Cardioprotection.- 5.5. Are Other Stress Proteins Cardioprotective .- Concluding Remarks.- 6. Involvement of Heat Shock Proteins in Protection of Various Normal and Tumor Cells from Ischemic Insult.- 6.1. HSPs and Ischemic Tolerance in the Brain.- 6.2. Ischemic Tolerance in the Kidney.- 6.3. HSPs and Protection from Ischemia of Other Organs and Tissues.- 6.4.- Concluding Remarks.- 7. What Are the Mechanisms of Heat Shock Protein-Mediated Cytoprotection Under ATP Deprivation .- 7.1. Two Paradigms of Cell Tolerance to ATP Deprivation: Reduced Injury During the Stress and the Improved Post-Stress Recovery.- 7.2. Chaperoning Under ATP Depletion as a Special Function of HSP70.- 7.3. How Other Stress Proteins Might Maintain the Viability of ATP-Deprived Cells.- 7.4. How Do HSPs Protect Cells against Necrosis during ATP Depletion .- 8. Mechanisms of Heat Shock Protein-Mediated Protection from Ischemia-Induced Apoptosis.- 8.1. HSPs and Triggering of Apoptosis in Ischemic Cells.- 8.2. HSPs and Transduction of the Apoptotic Signal.- 8.3. HSPs and the Execution of Apoptosis.- 9. Conclusions and Perspectives.- 9.1. Adaptation to Energy Starvation on The Molecular Level.- 9.2. Heat Shock Proteins and Ischemia: Significance for Medicine.- Concluding Remarks. 256 pp. Englisch. Seller Inventory # 9781461377528
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Heat Shock Proteins and Cytoprotection
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. 1. Heat Shock Proteins and the Regulation of Heat Shock Gene Expression in Eukaryotes.- 1.1. The Family of Stress Proteins and Molecular Chaperones.- 1.2. The Regulation of Heat Shock Gene Expression in Eukaryotes.- Concluding Remarks.- 2. ATP Homeostasis, . Seller Inventory # 4195877
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Heat Shock Proteins and Cytoprotection : Atp-Deprived Mammalian Cells
Seller: AHA-BUCH GmbH, Einbeck, Germany
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - 1. Heat Shock Proteins and the Regulation of Heat Shock Gene Expression in Eukaryotes.- 1.1. The Family of Stress Proteins and Molecular Chaperones.- 1.2. The Regulation of Heat Shock Gene Expression in Eukaryotes.- Concluding Remarks.- 2. ATP Homeostasis, Ionic Balance and Cell Viability.- 2.1. ATP Homeostasis in Mammalian Cells.- 2.2. Cell Viability and ATP Depletion.- 2.3. Significance of Ionic Imbalance for the Death of ATP-Depleted Cells.- 2.4. Mitochondrial Dysfunction and Damage During Ischemia.- Concluding Remarks.- 3. ¿Proteotoxicity¿ of ATP Depletion: Disruption of the Cytoskeleton, Protein Aggregation and Involvement of Molecular Chaperones.- 3.1. The Cytoskeleton Under ATP Deprivation.- 3.2. Protein Aggregation in Energy-Deprived Cells.- 3.3. How Do Heat Shock Proteins Respond to ATP Depletion .- Concluding Remarks.- 4. ATP Depletion as Inducer of Heat Shock Protein Expression.- 4.1. Anoxia and Mitochondrial Inhibitors Activate HSP Gene Expression.- 4.2. Ischemia-Induced HSP Synthesis in the Heart.- 4.3. Stress Protein Expression in Post-Ischemic Brain.- 4.4. Ischemia-Induced Stress Protein Synthesis in Other Normal Tissues and Tumor Cells.- 4.5. Possible Mechanisms of HSP Accumulation After ATP Depletion.- Concluding Remarks.- 5. Heat Shock Proteins and Cardioresistance to Ischemia.- 5.1. Heat Shock-Induced Cardioresistance to Ischemia/Reperfusion Injury.- 5.2. The Role of Myocardial HSPs in Ischemie Preconditioning.- 5.3. The Cardioresistance Induced by Other Stimuli Can Also Be Associated with HSPs.- 5.4. Evidence for the Involvement of HSP70 in Cardioprotection.- 5.5. Are Other Stress Proteins Cardioprotective .- Concluding Remarks.- 6. Involvement of Heat Shock Proteins in Protection of Various Normal and Tumor Cells from Ischemic Insult.- 6.1. HSPs and Ischemic Tolerance in the Brain.- 6.2. Ischemic Tolerance in the Kidney.- 6.3. HSPs and Protection from Ischemia of Other Organs and Tissues.- 6.4.- Concluding Remarks.- 7. What Are the Mechanisms of Heat Shock Protein-Mediated Cytoprotection Under ATP Deprivation .- 7.1. Two Paradigms of Cell Tolerance to ATP Deprivation: Reduced Injury During the Stress and the Improved Post-Stress Recovery.- 7.2. Chaperoning Under ATP Depletion as a Special Function of HSP70.- 7.3. How Other Stress Proteins Might Maintain the Viability of ATP-Deprived Cells.- 7.4. How Do HSPs Protect Cells against Necrosis during ATP Depletion .- 8. Mechanisms of Heat Shock Protein-Mediated Protection from Ischemia-Induced Apoptosis.- 8.1. HSPs and Triggering of Apoptosis in Ischemic Cells.- 8.2. HSPs and Transduction of the Apoptotic Signal.- 8.3. HSPs and the Execution of Apoptosis.- 9. Conclusions and Perspectives.- 9.1. Adaptation to Energy Starvation on The Molecular Level.- 9.2. Heat Shock Proteins and Ischemia: Significance for Medicine.- Concluding Remarks. Seller Inventory # 9781461377528
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Heat Shock Proteins and Cytoprotection: Atp-Deprived Mammalian Cells
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Springer-Verlag New York Inc., 2012
ISBN 10: 1461377528
ISBN 13: 9781461377528
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Heat Shock Proteins and Cytoprotection: Atp-Deprived Mammalian Cells (Molecular Biology Intelligence Unit)
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