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Synopsis
Upon infection the host needs to mount vigorous immune response against pathogen in order to successfully control its replication. However, once the infectious agent is controlled or eliminated, host cells need to signal the immune system to slow or cease its activities. While vast knowledge has been accumulated through the years on the mechanisms involved in the initiation and effector phases of the immune responses, the pathways triggered in order to modulate or end innate and acquired immunity are becoming more evident as evidence for its relevance comes to surface. Due to its biological power, evidence has surfaced indicating that eventually pathogens may take advantage of such regulatory pathways in order to escape effector mechanisms and progress to persistence. This book will discuss several cellular pathways involved in controlling immune response in the context of infectious diseases, their biological consequences and potential "hijack" of these pathways for the benefit of pathogen leading towards pathogen persistence as opposed to clearance.
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The interface between host and pathogen cells involves a complex series of molecular mechanisms. On one side host cells recognize pathogen structures and initiate immune responses. On the other side, pathogens continually evolve immune escape strategies aiming at establishing chronic disease and transmission to a new host. The balance between those two forces can determine the fate of infectious diseases. Either uncontrolled pathogen replication or tissue damage due to unleashed pro-inflammatory responses can be detrimental to the host.
Here we explore immune regulatory mechanisms that take place during some of the most relevant infectious diseases worldwide. We provide a wide spectrum view of the current understanding of how the immune system modulates ongoing responses to prevent host pathology, as well as some immune evasion strategies used by some of those microbes.
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Control of Innate and Adaptive Immune Responses during Infectious Diseases
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Springer New York, Springer US Sep 2011, 2011
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Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Upon infection the host needs to mount vigorous immune response against pathogen in order to successfully control its replication. However, once the infectious agent is controlled or eliminated, host cells need to signal the immune system to slow or cease its activities. While vast knowledge has been accumulated through the years on the mechanisms involved in the initiation and effector phases of the immune responses, the pathways triggered in order to modulate or end innate and acquired immunity are becoming more evident as evidence for its relevance comes to surface. Due to its biological power, evidence has surfaced indicating that eventually pathogens may take advantage of such regulatory pathways in order to escape effector mechanisms and progress to persistence. This book will discuss several cellular pathways involved in controlling immune response in the context of infectious diseases, their biological consequences and potential 'hijack' of these pathways for the benefit of pathogen leading towards pathogen persistence as opposed to clearance. 188 pp. Englisch. Seller Inventory # 9781461404835
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Gebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Explores immune regulatory mechanisms that take place during some of the most relevant infectious diseases worldwide Provides a wide spectrum understanding of the immune system modulates ongoing responses to prevent host pathology Full-colo. Seller Inventory # 4196838
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Control of Innate and Adaptive Immune Responses during Infectious Diseases
Published by
Springer New York, Springer US Sep 2011, 2011
ISBN 10: 1461404835
ISBN 13: 9781461404835
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Buch. Condition: Neu. Neuware -Upon infection the host needs to mount vigorous immune response against pathogen in order to successfully control its replication. However, once the infectious agent is controlled or eliminated, host cells need to signal the immune system to slow or cease its activities. While vast knowledge has been accumulated through the years on the mechanisms involved in the initiation and effector phases of the immune responses, the pathways triggered in order to modulate or end innate and acquired immunity are becoming more evident as evidence for its relevance comes to surface. Due to its biological power, evidence has surfaced indicating that eventually pathogens may take advantage of such regulatory pathways in order to escape effector mechanisms and progress to persistence. This book will discuss several cellular pathways involved in controlling immune response in the context of infectious diseases, their biological consequences and potential 'hijack' of these pathways for the benefit of pathogen leading towards pathogen persistence as opposed to clearance.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 188 pp. Englisch. Seller Inventory # 9781461404835
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