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Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation - Softcover
Synopsis
"Transporters in Drug Development"examines how membrane transporters can be dealt with in academic industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of "in vitro" characterization of single transporters in theintestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating "in vitro" observed interaction of transporters into "in vivo" relevance are explored, and the book highlightsperspectives of applying targeted proteomics and mechanistic modeling in this process.
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