Computing for Comparative Microbial Genomics: Bioinformatics for Microbiologists (Computational Biology)

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9781848002548: Computing for Comparative Microbial Genomics: Bioinformatics for Microbiologists (Computational Biology)

Overview and Goals This book describes how to visualize and compare bacterial genomes. Sequencing technologies are becoming so inexpensive that soon going for a cup of coffee will be more expensive than sequencing a bacterial genome. Thus, there is a very real and pressing need for high-throughput computational methods to compare hundreds and thousands of bacterial genomes. It is a long road from molecular biology to systems biology, and in a sense this text can be thought of as a path bridging these ? elds. The goal of this book is to p- vide a coherent set of tools and a methodological framework for starting with raw DNA sequences and producing fully annotated genome sequences, and then using these to build up and test models about groups of interacting organisms within an environment or ecological niche. Organization and Features The text is divided into four main parts: Introduction, Comparative Genomics, Transcriptomics and Proteomics, and ? nally Microbial Communities. The ? rst ? ve chapters are introductions of various sorts. Each of these chapters represents an introduction to a speci? c scienti? c ? eld, to bring all readers up to the same basic level before proceeding on to the methods of comparing genomes. First, a brief overview of molecular biology and of the concept of sequences as biological inf- mation are given.

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The problem many microbiologists face is simply that of too much information. This book details many published methods for comparison of genomes, and provides examples of how custom comparisons can be made. The choice of methods obviously depends on the questions to be asked, and of course on the quantity of genomes to be compared. Two similar bacterial chromosomes can simply be aligned with each other, and regions of inversions and deletions can be readily visualised. However, this method won’t work to compare hundreds of genomes, where 2-Dimensional clustering heat maps would be useful.

This text is built around teaching COMPUTATIONAL / BIOINFORMATIC methods for comparison of microbial genomes, and includes detailed examples of how to compare them at the level of DNA, RNA, and protein, in terms of structural / functional analysis.

Aimed at advanced undergraduate and graduate students in Bioinformatics and Microbiology, this book will prove an invaluable reference to computational and bioinformatics tools.

From the Back Cover:

The major difficulty many microbiologists face is simply that of too much information. As a result of sequencing technologies becoming so economical, there is a very real and pressing need for high-throughput computational methods to compare hundreds and thousands of bacterial genomes.

This accessible text/reference provides a coherent set of tools and a methodological framework for comparing raw DNA sequences and fully annotated genome sequences, then using these to build up and test models about groups of interacting organisms within an environment or ecological niche. Easy-to-follow, this introductory textbook is built around teaching computational / bioinformatics methods for comparison of microbial genomes, and includes detailed examples of how to compare them at the level of DNA, RNA, and protein, in terms of structural and functional analysis.

Topics and Features:

• Contains five introductory chapters each representing a specific scientific field, to bring all readers up to the same basic level

• Familiarizes readers with genome sequences, RNA sequences (transcriptomics), proteomics and regulation of gene expression

• Describes basic methods to compare genomes and visualize the results for easy interpretation

• Discusses microbial communities, providing a framework for analysing and comparing individual genomes or raw DNA derived from complete ecosystems

• Introduces various atlases, building up to the Genome Atlas

• Offers numerous helpful examples throughout

• Focuses on the use and interpretation of publicly available Web tools

• Provides supplemental resources, such as Web links, at http://comparativemicrobial.com

Developed from a set of lectures for a course in Comparative Microbial Genomics taught since 2001, this wide-ranging foundational textbook is aimed at advanced undergraduate and graduate students in Bioinformatics and Microbiology. The authors are from diverse backgrounds complementing the interdisciplinary nature of the topic and consequently have developed a common scientific language. Readers will find this text an invaluable reference for computational and bioinformatics tools.

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David W. Ussery, Trudy M. Wassenaar, Stefano Borini
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ISBN 10: 1848002548 ISBN 13: 9781848002548
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Book Description Springer London Ltd, United Kingdom, 2009. Mixed media product. Book Condition: New. 2009.. 231 x 157 mm. Language: English . Brand New Book. Overview and Goals This book describes how to visualize and compare bacterial genomes. Sequencing technologies are becoming so inexpensive that soon going for a cup of coffee will be more expensive than sequencing a bacterial genome. Thus, there is a very real and pressing need for high-throughput computational methods to compare hundreds and thousands of bacterial genomes. It is a long road from molecular biology to systems biology, and in a sense this text can be thought of as a path bridging these ? elds. The goal of this book is to p- vide a coherent set of tools and a methodological framework for starting with raw DNA sequences and producing fully annotated genome sequences, and then using these to build up and test models about groups of interacting organisms within an environment or ecological niche. Organization and Features The text is divided into four main parts: Introduction, Comparative Genomics, Transcriptomics and Proteomics, and ? nally Microbial Communities. The ? rst ? ve chapters are introductions of various sorts. Each of these chapters represents an introduction to a speci? c scienti? c ? eld, to bring all readers up to the same basic level before proceeding on to the methods of comparing genomes. First, a brief overview of molecular biology and of the concept of sequences as biological inf- mation are given. Bookseller Inventory # AAZ9781848002548

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David W. Ussery, Trudy M. Wassenaar, Stefano Borini
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Book Description Springer London Ltd, United Kingdom, 2009. Mixed media product. Book Condition: New. 2009.. 231 x 157 mm. Language: English . Brand New Book. Overview and Goals This book describes how to visualize and compare bacterial genomes. Sequencing technologies are becoming so inexpensive that soon going for a cup of coffee will be more expensive than sequencing a bacterial genome. Thus, there is a very real and pressing need for high-throughput computational methods to compare hundreds and thousands of bacterial genomes. It is a long road from molecular biology to systems biology, and in a sense this text can be thought of as a path bridging these ? elds. The goal of this book is to p- vide a coherent set of tools and a methodological framework for starting with raw DNA sequences and producing fully annotated genome sequences, and then using these to build up and test models about groups of interacting organisms within an environment or ecological niche. Organization and Features The text is divided into four main parts: Introduction, Comparative Genomics, Transcriptomics and Proteomics, and ? nally Microbial Communities. The ? rst ? ve chapters are introductions of various sorts. Each of these chapters represents an introduction to a speci? c scienti? c ? eld, to bring all readers up to the same basic level before proceeding on to the methods of comparing genomes. First, a brief overview of molecular biology and of the concept of sequences as biological inf- mation are given. Bookseller Inventory # AAZ9781848002548

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Book Description Springer London Ltd 2008-12-22, England, 2008. multimedia item. Book Condition: New. Bookseller Inventory # 9781848002548

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Book Description Springer London Ltd. Mixed media product. Book Condition: new. BRAND NEW, Computing for Comparative Microbial Genomics: Bioinformatics for Microbiologists, David W. Ussery, Trudy M. Wassenaar, Stefano Borini, Overview and Goals This book describes how to visualize and compare bacterial genomes. Sequencing technologies are becoming so inexpensive that soon going for a cup of coffee will be more expensive than sequencing a bacterial genome. Thus, there is a very real and pressing need for high-throughput computational methods to compare hundreds and thousands of bacterial genomes. It is a long road from molecular biology to systems biology, and in a sense this text can be thought of as a path bridging these ? elds. The goal of this book is to p- vide a coherent set of tools and a methodological framework for starting with raw DNA sequences and producing fully annotated genome sequences, and then using these to build up and test models about groups of interacting organisms within an environment or ecological niche. Organization and Features The text is divided into four main parts: Introduction, Comparative Genomics, Transcriptomics and Proteomics, and ? nally Microbial Communities. The ? rst ? ve chapters are introductions of various sorts. Each of these chapters represents an introduction to a speci? c scienti? c ? eld, to bring all readers up to the same basic level before proceeding on to the methods of comparing genomes. First, a brief overview of molecular biology and of the concept of sequences as biological inf- mation are given. Bookseller Inventory # B9781848002548

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Book Description Mixed media product. Book Condition: New. Not Signed; Overview and Goals This book describes how to visualize and compare bacterial genomes. Sequencing technologies are becoming so inexpensive that soon going for a cup of coffee will be more expensive than sequencing a bacterial genome. Thus, there is a very real and pressing need for high-throughput c. book. Bookseller Inventory # ria9781848002548_rkm

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Book Description Springer London Ltd, 2008. Book Condition: New. 2008. 2009th Edition. Hardcover. The problem many microbiologists face is simply that of too much information. Built around teaching computational and bioinformatic methodology, this book details published methods for comparing genomes and provides examples of how to make custom comparisons. Series: Computational Biology. Num Pages: 270 pages, 2 black & white tables, 2 colour tables, biography. BIC Classification: PSG; U. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 247 x 163 x 17. Weight in Grams: 394. . . . . . . Bookseller Inventory # V9781848002548

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Book Description Springer London Ltd. Book Condition: New. 2008. 2009th Edition. Hardcover. The problem many microbiologists face is simply that of too much information. Built around teaching computational and bioinformatic methodology, this book details published methods for comparing genomes and provides examples of how to make custom comparisons. Series: Computational Biology. Num Pages: 270 pages, 2 black & white tables, 2 colour tables, biography. BIC Classification: PSG; U. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 247 x 163 x 17. Weight in Grams: 394. . . . . . Books ship from the US and Ireland. Bookseller Inventory # V9781848002548

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Book Description Springer, 2009. Hardback. Book Condition: NEW. 9781848002548 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. Bookseller Inventory # HTANDREE0310512

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