Synopsis
1. Foreword
2. Mast cell ontogeny
2.1. Background
2.2. First evidence of bone marrow origin
2.3. Development of mast cells along the myeloid pathway2.4. Stem cell factor
2.5. Integrins and cell adhesion molecules
2.6. Chemokine receptors and interleukins
3. Staining of mast cells
3.1.Background
3.2. Metachromasia3.3. Alcian blue-safranin
3.4. The tyrosine kinase kit receptor
3.5. Tryptase and chymase3.6. Other stainings
4. Mast cells heterogeneity
4.1. Background
4.2. Mast cells in thymus4.3. Mast cells in duodenum
4.4. Mast cells in mammary gland
4.5. Other localizations4.6. Mechanistic insights
5. Mast cell biology and functions
5.1.Background
5.2.Mast cell derived secretory products5.3.Mast cell immunological functions
5.4.Mast cell non-immunological functions
6. Mast cells in arteriogenesis
6.1.Background
6.2.Factors involved in angiogenesis and arteriogenesis6.3.Inflammatory cells in arteriogenesis
6.4.Mast cells in arteriogenesis
6.5.Perspectives
7. Mast cells in primary systemic vasculitides
7.1.Background
7.2.Experimental evidence of the involvement of mast cells in vasculitides
7.3.Clinical evidence of the involvement of mast cells in vasculitides
7.4.Therapeutic perespectives
8. Mast cells in blood-brain barrier alterations and neurodegenerative diseases
8.1.The blood-brain barrier
8.2.Mast cells in the brain
8.3.Mast cells in cerebral ischemia
8.4.Mast cells in multiple sclerosis8.5.Mast cells in angiogenesis in diseases associated with blood brain barrier alterations
8.6.Perspectives
9. Mast cells and basophils: a link between angiogenesis and inflammation in allergic diseases
9.1.General biology and mediators of mast cells and basophils
9.2.Mast cells and basophils in allergy9.3.Mast cells and basophils in inflammation, angiogenesis and tissue remodeling
10. Mast cells in tumor fate
10.1. Tumor microenvironment
10.2. Mast cells and tumor growth: pros and cons
11. Mast cells in tumor angiogenesis and lymphoangiogenesis
11.1. Mediators released by human mast cells involved in the angiogenic response
11.2. The CAM assay in the study of mast cell-induced angiogenesis
11.3. Mast cells in experimental tumor angiogenesis
11.4. Mast cells and angiogenesis in solid tumors
11.5. Mast cells and angiogenesis in haematological malignancies
11.6. Mast cells in tum
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