Tuberculosis Host-Pathogen Interactions - Hardcover

Hardcover

ISBN 10: 3030253805 ISBN 13: 9783030253806

Publisher: Springer, 2019

Synopsis

This book summarizes the progress in studies of tuberculosis host-pathogen interactions from several perspectives: molecular microbiology, immunology, animal models, clinical studies, epidemiology, and drug discovery.

Tuberculosis (TB) remains a severe global public health problem. Complex interactions between environmental, microbial and host factors lead to clinically relevant infections.  Studies on bacterial virulence, host-genetic, and immunological factors contributing to the susceptibility to TB provide an ever-growing foundation of knowledge that is critical to finding new interventions.  Studies of immune mechanisms against M. tuberculosis infection have identified immunological markers associated with specific phenotypes in the host, providing insight into how they may be used to augment current treatment strategies. Recent advances in diagnosis, therapeutics and vaccines, as well as basic-research oriented studies have shed light on the development of new directions for prevention, treatment and control of TB. Improved understanding of the interplay between the bacterium and host is a key component of reducing incidence worldwide. 

About this title

About the Author

Dr. Jeffrey D. Cirillo is a Regents’ Professor at Texas A&M University College of Medicine and the Director of the Center for Airborne Pathogens Research and Imaging with over 30 years of research in tuberculosis.

Dr. Ying Kong is an Assistant Professor at the University of Tennessee Health Science Center with over 16 years of research in tuberculosis.

From the Back Cover

Historically, tuberculosis was one of the first organisms associated with disease. Yet, despite progress, tuberculosis remains the most frequent cause of death in humans due to a single infectious agent. This text describes some of the recent, state-of-the-art advances related to our understanding of how this organism causes disease in humans, its mechanisms involved in parasitizing the host, as well as how the host resists or becomes susceptible to infection. We cover several of the molecular, biochemical and structural aspects of the bacterium responsible, Mycobacterium tuberculosis, and describe individual components of the host response and how these impact the course of disease. Although we cover only a very small portion of the field in this overview, we believe that there is a great deal of novel information present that will be valuable to any researcher or student of the field.  We are at a stage where there are often more questions than answers, but use of the foundation that is now developing through the effort of tuberculosis researchers provides us with opportunities previously out of reach. This text provides overviews of the field in a number of different areas that will engage researchers interested in tuberculosis, and provide suggestions for ways to move forward.  All of the authors hope that readers enjoy this taste of each area, and that their contributions will help others to make additional progress.

Dr. Jeffrey D. Cirillo is a Regents’ Professor at Texas A&M University College of Medicine and the Director of the Center for Airborne Pathogens Research and Imaging with over 30 years of research in tuberculosis.

Dr. Ying Kong is an Assistant Professor at the University of Tennessee Health Science Center with over 16 years of research in tuberculosis.

Edition details

• Publisher: Springer
• Publication date: 2019
• Language: English
• ISBN 10: 3030253805
• ISBN 13: 9783030253806
• Binding: Hardcover
• Edition number: 1
• Number of pages: 263
• Editor: Cirillo Jeffrey D., Kong Ying