This book covers a hot subject in cell biology; how the cell environme nt sends messages to the cell, regulates gene expression, and modulate s the cell phenotype. For a long time the extracellular matrix was bel ieved to have only a supporting role for cell attachment. However, it became apparent that the matrix participates actively in cell metaboli sm. The experiments that led to this conclusion are described in this volume. Progressively, molecules have been identified that transmit th is signaling at the cell-matrix interface. Their identity and mechanis m of action are also illustrated in this book. Finally, it explains th e role the cell-matrix relationship plays in the regulation of cell pr oliferation, cell differentiation, and the expression of malignancy.
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