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Telomeres and Telomerase in Aging, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing - Hardcover
Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.
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The understanding of the molecular mechanisms underlying the ageing process is essential to improve quality of life and ‘health span’ in the growing populations of the elderly.
Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes experimental evidence and clinical data indicating that telomere dysfunction influences human ageing, diseases and cancer. In addition, the book describes our current knowledge on checkpoints that limit cellular lifespan (senescence) and survival (apoptosis, crisis) in response to telomere dysfunction.
A special focus of the book is on adult stem cells. There is emerging evidence that adult stem cell ageing impairs organismal fitness and survival and contributes to cancer formation (cancer stem cells). The book summarizes basic mechanisms of adult stem cell ageing. Moreover, the authors describe evidence that telomere dysfunction impairs stem cell function by inducing cell intrinsic checkpoints as well as environmental alterations.
All of these subjects are of great interest for ageing researchers, physicians and students and should provide a rational basis for beginning to identify molecular targets for novel therapies that aim to improve quality of life during ageing.
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- PublisherSpringer
- Publication date2007
- ISBN 10 3540737081
- ISBN 13 9783540737087
- BindingHardcover
- Number of pages344
- EditorRudolph K. Lenhard
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Telomeres and Telomerase in Aging, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing
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Telomeres and Telomerase in Aging, Disease, and Cancer
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Provides an in depth review of our current knowledge on the role of telomeres and telomerase in ageing, disease and cancerSpecial focus is on adult stem cellsDescribes future directions in research on adult stem cell ageing, telomeres, and . Seller Inventory # 4899765
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Telomeres and Telomerase in Ageing; Disease; and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing
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Book Description Condition: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book. Seller Inventory # ria9783540737087_lsuk
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Telomeres and Telomerase in Aging, Disease, and Cancer
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Book Description Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells. 344 pp. Englisch. Seller Inventory # 9783540737087
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Telomeres and Telomerase in Aging, Disease, and Cancer : Molecular Mechanisms of Adult Stem Cell Ageing
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Book Description Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells. Seller Inventory # 9783540737087
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Telomeres and Telomerase in Ageing, Disease, and Cancer
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Book Description Hardcover. Condition: New. First Edition. First Edition thus, as good as new. Telomeres and Telomerase in Ageing, Disease, and Cancer by Various Authors. Published by Springer in 2007. Hardcover ISBN:9783540737087. Collectible item in excellent condition. Seller Inventory # 3540737087
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Book Description Condition: New. pp. 344. Seller Inventory # 26459596
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Book Description Condition: New. pp. 344 Illus. Seller Inventory # 7388307
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