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Oncogenes Meet Metabolism: From Deregulated Genes to a Broader Understanding of Tumour Physiology (Ernst Schering Foundation Symposium Proceedings, 2007/4) - Hardcover
Synopsis
In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).
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- PublisherSpringer
- Publication date2008
- ISBN 10 3540794778
- ISBN 13 9783540794776
- BindingHardcover
- Number of pages280
- EditorKroemer Guido, Mumberg Dominik, Keun Kector, Riefke Björn, Steger-Hartmann Thomas, Petersen Kirstin
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Oncogenes meet metabolism : from deregulated genes to a broader understanding of tumour physiology
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Oncogenes Meet Me. From Deregulated Genes to a Broader Understanding of Tumour Physiology. Edited by G. Groemer, D. Mumberg, H. Keund a.o. (Ernst Schering Foundation Symposium Proceedings 2007-4).
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ONCOGENES MEET METABOLISM: FROM DEREGULATED GENES TO A BROADER UNDERSTANDING OF TUMOUR PHYSIOLOGY
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Oncogenes Meet Metabolism : From Deregulated Genes to a Broader Understanding of Tumour Physiology
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