Synopsis
1 Xenobiotic Metabolism: From Intact Biosystem to Single Enzymes.- 2 Regulation of Xenobiotic-Metabolizing Cytochromes P450.- 3 Cytochrome P450 in Human Drug Metabolism: How Much Is Predictable?.- 4 Metabolic Activation of Anticancer Oxazaphosphorines by Cytochrome P450s: Development of a Model for Cancer Gene Therapy.- 5 The Use of Bacteria for Cytochrome P450 Expression.- 6 Expression of Cytochromes P450 in Yeast: Practical Aspects.- 7 Human Cells as an Expression System for Cytochromes P450.- 8 Metabolic Reactions and Recombinant Isoenzymes of Cytochrome P450: Information Generated and Value for Pharmaceutical Development.- 9 The Importance of Cytochrome P450 3A Enzymes in Drug Metabolism.- 10 Strategies for Verifying the Involvement of Specific Cytochrome P450 Enzymes in Xenobiotic Metabolism.- 11 Regulation of Cytochromes P450 by Substrate Interactions.- 12 Strategies for the Use of Single Cytochrome P450 Enzymes in Drug Research and Future Prospects.
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