Introduction to Computational Biology: An Evolutionary Approach

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9783764367008: Introduction to Computational Biology: An Evolutionary Approach
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Written with the advanced undergraduate in mind, this book introduces into the field of Bioinformatics. The authors explain the computational and conceptional background to the analysis of large-scale sequence data. Many of the corresponding analysis methods are rooted in evolutionary thinking, which serves as a common thread throughout the book. The focus is on methods of comparative genomics and subjects covered include: alignments, gene finding, phylogeny, and the analysis of single nucleotide polymorphisms (SNPs). The volume contains exercises, questions & answers to selected problems.

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Molecular biology has changed dramatically over the past two decades. Until the early 1990s genes were studied one at a time by small teams of researchers; today entire genomes are sequenced by internationally collaborating laboratories. In the bygone gene-centered era the accumulation of data was the rate-limiting step in research. Now that step is often data interpretation. This is increasingly dependent on computational methods and as a consequence, computational biology has emerged in the past decade as a new subdiscipline of biology.

This introduction to computational biology is centered on the analysis of molecular sequence data. There are two closely connected aspects to biological sequences: (i) their relative position in the space of all other sequences, and (ii) their movement through this sequence space in evolutionary time. Accordingly, the first part of the book deals with classical methods of sequence analysis: pairwise alignment, exact string matching, multiple alignment, and hidden Markov models. In the second part evolutionary time takes center stage and phylogenetic reconstruction, the analysis of sequence variation, and the dynamics of genes in populations are explained in detail. In addition, the book contains a computer program with a graphical user interface that allows the reader to experiment with a number of key concepts developed by the authors.

Introduction to Computational Biology is intended for students enrolled in courses in computational biology or bioinformatics as well as for molecular biologists, mathematicians, and computer scientists.

Bernhard Haubold is associate professor at the University of Applied Sciences, Weihenstephan, Germany. Thomas Wiehe is associate professor at the University of Cologne, Germany.

Review:

From the reviews: “Haubold and Weihe is precisely addressed to this increasingly large circle of people using sequences ... an introduction to the computational aspects of genomics and the interpretation of sequence biological data. ... Each chapter ends with a small section of interesting exercises and accompanying answers ... . These make the book very useful for students in bioinformatics but also for researchers and students in molecular biology, genetics, medicine or at the other end students in computer sciences or mathematics interested in molecular biology.” (Andrei Petrescu, Romanian Journal of Biochemistry, Vol. 47 (1), 2010)

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Book Description Birkhauser Boston, 2007. Hardcover. Condition: New. Molecular biology has changed dramatically over the past two decades. Until the early 1990s genes were studied one at a time by small teams of researchers; today entire genomes are sequenced by internationally collaborating laboratories. In the bygone gene-centered era the accumulation of data was the rate-limiting step in research. Now that step is often data interpretation. This is increasingly dependent on computational methods and as a consequence, computational biology has emerged in the past decade as a new subdiscipline of biology. This introduction to computational biology is centered on the analysis of molecular sequence data. There are two closely connected aspects to biological sequences: (i) their relative position in the space of all other sequences, and (ii) their movement through this sequence space in evolutionary time. Accordingly, the first part of the book deals with classical methods of sequence analysis: pairwise alignment, exact string matching, multiple alignment, and hidden Markov models. In the second part evolutionary time takes center stage and phylogenetic reconstruction, the analysis of sequence variation, and the dynamics of genes in populations are explained in detail. In addition, the book contains a computer program with a graphical user interface that allows the reader to experiment with a number of key concepts developed by the authors. Introduction to Computational Biology is intended for students enrolled in courses in computational biology or bioinformatics as well as for molecular biologists, mathematicians, and computer scientists. Bernhard Haubold is associate professor at the University of Applied Sciences, Weihenstephan, Germany. Thomas Wiehe is associate professor at the University of Cologne, Germany. Seller Inventory # 218048

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