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Synopsis
The immune system has evolved mechanisms enabli ng it to discriminate between self and non-self constituents. A normally functioning organism is naturally unresponsive to self antigens originating from clonal deletion, aner- gy, or an active suppression of self-reactive T cells. The wide spectrum of autoimmune responses may be divided into systemic and organ-specific dis- eases and encompasses the actions of autoantibodies, autoantigeu-autoanti- body complexes, and sensitized T lymphocytes. The aim of this book is to review the current understandin g, concepts and hypotheses regarding the pathogenesis and therapeutic approaches in autoim- mune disorders. The first six articles are generally concerned with the mech- anisms operating in autoimmune phenomena, whereas the subsequent reviews discuss particular phenomena in representative autoimmune dis- eases. The introductory article underlines the significance of the interactions between antigen-specific T cells and other elements ot the immune system and proposes that not suppression, but rather activation of the immune sys- tem, leading to a redirection of the immune response, would be therapeuti- cally beneficial. The next articles present the importance of costim ulatory signals in determining various types of immune responses, including autoim- munity, and the role of regulatory T cells. Further, an interesting phenome- non of epitope spreading as a mechanism for the progression of autoimmune diseases is presented.
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Autoimmunity (eng)
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Autoimmunity
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Autoimmunity
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Springer Netherlands Sep 2012, 2012
ISBN 10: 9401038775
ISBN 13: 9789401038775
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The immune system has evolved mechanisms enabli ng it to discriminate between self and non-self constituents. A normally functioning organism is naturally unresponsive to self antigens originating from clonal deletion, aner gy, or an active suppression of self-reactive T cells. The wide spectrum of autoimmune responses may be divided into systemic and organ-specific dis eases and encompasses the actions of autoantibodies, autoantigeu-autoanti body complexes, and sensitized T lymphocytes. The aim of this book is to review the current understandin g, concepts and hypotheses regarding the pathogenesis and therapeutic approaches in autoim mune disorders. The first six articles are generally concerned with the mech anisms operating in autoimmune phenomena, whereas the subsequent reviews discuss particular phenomena in representative autoimmune dis eases. The introductory article underlines the significance of the interactions between antigen-specific T cells and other elements ot the immune system and proposes that not suppression, but rather activation of the immune sys tem, leading to a redirection of the immune response, would be therapeuti cally beneficial. The next articles present the importance of costim ulatory signals in determining various types of immune responses, including autoim munity, and the role of regulatory T cells. Further, an interesting phenome non of epitope spreading as a mechanism for the progression of autoimmune diseases is presented. 220 pp. Englisch. Seller Inventory # 9789401038775
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Autoimmunity
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The Paradigms of Causality and Treatment for Autoimmune Disease I.R. Cohen. Uncovering the Differences between T Cell Tolerance and Immunity A.T. Vella. The Physiological Role of Regulatory T Cells in the Prevention of Autoimmunity: Generation, Specif. Seller Inventory # 5830676
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Autoimmunity
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Taschenbuch. Condition: Neu. Autoimmunity | Andrzej Górski (u. a.) | Taschenbuch | vii | Englisch | 2012 | Springer Netherland | EAN 9789401038775 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. Seller Inventory # 105931156
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Autoimmunity
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Condition: New. pp. 222 Index. Seller Inventory # 26142319819
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Autoimmunity
Published by
Springer Netherlands, Springer Netherlands Sep 2012, 2012
ISBN 10: 9401038775
ISBN 13: 9789401038775
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Taschenbuch
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The immune system has evolved mechanisms enabli ng it to discriminate between self and non-self constituents. A normally functioning organism is naturally unresponsive to self antigens originating from clonal deletion, aner gy, or an active suppression of self-reactive T cells. The wide spectrum of autoimmune responses may be divided into systemic and organ-specific dis eases and encompasses the actions of autoantibodies, autoantigeu-autoanti body complexes, and sensitized T lymphocytes. The aim of this book is to review the current understandin g, concepts and hypotheses regarding the pathogenesis and therapeutic approaches in autoim mune disorders. The first six articles are generally concerned with the mech anisms operating in autoimmune phenomena, whereas the subsequent reviews discuss particular phenomena in representative autoimmune dis eases. The introductory article underlines the significance of the interactions between antigen-specific T cells and other elements ot the immune system and proposes that not suppression, but rather activation of the immune sys tem, leading to a redirection of the immune response, would be therapeuti cally beneficial. The next articles present the importance of costim ulatory signals in determining various types of immune responses, including autoim munity, and the role of regulatory T cells. Further, an interesting phenome non of epitope spreading as a mechanism for the progression of autoimmune diseases is presented.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 220 pp. Englisch. Seller Inventory # 9789401038775
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Autoimmunity
Published by
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ISBN 10: 9401038775
ISBN 13: 9789401038775
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - The immune system has evolved mechanisms enabli ng it to discriminate between self and non-self constituents. A normally functioning organism is naturally unresponsive to self antigens originating from clonal deletion, aner gy, or an active suppression of self-reactive T cells. The wide spectrum of autoimmune responses may be divided into systemic and organ-specific dis eases and encompasses the actions of autoantibodies, autoantigeu-autoanti body complexes, and sensitized T lymphocytes. The aim of this book is to review the current understandin g, concepts and hypotheses regarding the pathogenesis and therapeutic approaches in autoim mune disorders. The first six articles are generally concerned with the mech anisms operating in autoimmune phenomena, whereas the subsequent reviews discuss particular phenomena in representative autoimmune dis eases. The introductory article underlines the significance of the interactions between antigen-specific T cells and other elements ot the immune system and proposes that not suppression, but rather activation of the immune sys tem, leading to a redirection of the immune response, would be therapeuti cally beneficial. The next articles present the importance of costim ulatory signals in determining various types of immune responses, including autoim munity, and the role of regulatory T cells. Further, an interesting phenome non of epitope spreading as a mechanism for the progression of autoimmune diseases is presented. Seller Inventory # 9789401038775
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Autoimmunity
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Autoimmunity
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Paperback. Condition: Brand New. reprint edition. 216 pages. 9.25x6.10x0.52 inches. In Stock. Seller Inventory # x-9401038775
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