Human Insulin: Clinical Pharmacological Studies in Normal Man

0 avg rating
( 0 ratings by Goodreads )
 
9789401083478: Human Insulin: Clinical Pharmacological Studies in Normal Man

Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human insulin in quantities sufficiently large for therapy has been made available by two techniques developed in parallel during the late 1970s. These involve either (i) formulation in E. coli bacteria suitably encoded by DNA recombinant methods of the A- and B-chains of human insulin followed by a chain combination reaction ('biosynthetic' human insulin) or (ii) enzymatic conversion (transpeptidation) of porcine insulin brought to react with a threonine ester by porcine trypsin in a mixture of water and organic solvents, yielding human insulin ('semi-synthetic' human insulin). This book includes the first clinical-pharmacological studies of each of the highly purified 'semi-synthetic' human insulin preparations: Actrapid ® HM; Monotard® HM; Protaphane® HM; Actraphane® HM; and Ultratard® HM (Novo Industri A/S, Copenhagen). The preliminary studies established their safety and efficacy relative to their porcine and bovine counterparts emphasising the relevance of species and formulation on the pharmacokinetics and biological responses to insulin. Additional investigations with human insulin demonstrated the influence of insulin concentration, site of administration, the addition of aprotinin to insulin and the mixing of 'short-' and 'intermediate-acting' formulations on insulin 'bioavailability'. Examination of the 'within' and 'between' subject day-to-day variation in absorption and the effect of subcutaneous insulin also demonstrates the dominating influence of insulin responsiveness.

"synopsis" may belong to another edition of this title.

Buy New View Book
List Price: US$ 99.00
US$ 93.13

Convert Currency

Shipping: US$ 5.17
From United Kingdom to U.S.A.

Destination, Rates & Speeds

Add to Basket

Top Search Results from the AbeBooks Marketplace

1.

Owens, D. R.
Published by Springer (2016)
ISBN 10: 9401083479 ISBN 13: 9789401083478
New Paperback Quantity Available: 1
Print on Demand
Seller:
Ria Christie Collections
(Uxbridge, United Kingdom)
Rating
[?]

Book Description Springer, 2016. Paperback. Book Condition: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Bookseller Inventory # ria9789401083478_lsuk

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 93.13
Convert Currency

Add to Basket

Shipping: US$ 5.17
From United Kingdom to U.S.A.
Destination, Rates & Speeds

2.

D. R. Owens
Published by Springer, Netherlands (2011)
ISBN 10: 9401083479 ISBN 13: 9789401083478
New Paperback Quantity Available: 10
Print on Demand
Seller:
The Book Depository US
(London, United Kingdom)
Rating
[?]

Book Description Springer, Netherlands, 2011. Paperback. Book Condition: New. Language: English . Brand New Book ***** Print on Demand *****. Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human insulin in quantities sufficiently large for therapy has been made available by two techniques developed in parallel during the late 1970s. These involve either (i) formulation in E. coli bacteria suitably encoded by DNA recombinant methods of the A- and B-chains of human insulin followed by a chain combination reaction ( biosynthetic human insulin) or (ii) enzymatic conversion (transpeptidation) of porcine insulin brought to react with a threonine ester by porcine trypsin in a mixture of water and organic solvents, yielding human insulin ( semi-synthetic human insulin). This book includes the first clinical-pharmacological studies of each of the highly purified semi-synthetic human insulin preparations: Actrapid (R) HM; Monotard (R) HM; Protaphane (R) HM; Actraphane (R) HM; and Ultratard (R) HM (Novo Industri A/S, Copenhagen). The preliminary studies established their safety and efficacy relative to their porcine and bovine counterparts emphasising the relevance of species and formulation on the pharmacokinetics and biological responses to insulin. Additional investigations with human insulin demonstrated the influence of insulin concentration, site of administration, the addition of aprotinin to insulin and the mixing of short- and intermediate-acting formulations on insulin bioavailability . Examination of the within and between subject day-to-day variation in absorption and the effect of subcutaneous insulin also demonstrates the dominating influence of insulin responsiveness. Softcover reprint of the original 1st ed. 1986. Bookseller Inventory # AAV9789401083478

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 98.69
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

3.

D. R. Owens
Published by Springer, Netherlands (2011)
ISBN 10: 9401083479 ISBN 13: 9789401083478
New Paperback Quantity Available: 10
Print on Demand
Seller:
The Book Depository
(London, United Kingdom)
Rating
[?]

Book Description Springer, Netherlands, 2011. Paperback. Book Condition: New. Language: English . Brand New Book ***** Print on Demand *****.Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human insulin in quantities sufficiently large for therapy has been made available by two techniques developed in parallel during the late 1970s. These involve either (i) formulation in E. coli bacteria suitably encoded by DNA recombinant methods of the A- and B-chains of human insulin followed by a chain combination reaction ( biosynthetic human insulin) or (ii) enzymatic conversion (transpeptidation) of porcine insulin brought to react with a threonine ester by porcine trypsin in a mixture of water and organic solvents, yielding human insulin ( semi-synthetic human insulin). This book includes the first clinical-pharmacological studies of each of the highly purified semi-synthetic human insulin preparations: Actrapid (R) HM; Monotard (R) HM; Protaphane (R) HM; Actraphane (R) HM; and Ultratard (R) HM (Novo Industri A/S, Copenhagen). The preliminary studies established their safety and efficacy relative to their porcine and bovine counterparts emphasising the relevance of species and formulation on the pharmacokinetics and biological responses to insulin. Additional investigations with human insulin demonstrated the influence of insulin concentration, site of administration, the addition of aprotinin to insulin and the mixing of short- and intermediate-acting formulations on insulin bioavailability . Examination of the within and between subject day-to-day variation in absorption and the effect of subcutaneous insulin also demonstrates the dominating influence of insulin responsiveness. Softcover reprint of the original 1st ed. 1986. Bookseller Inventory # AAV9789401083478

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 100.95
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

4.

D. R. Owens
Published by Springer, Netherlands (2011)
ISBN 10: 9401083479 ISBN 13: 9789401083478
New Paperback Quantity Available: 10
Seller:
Book Depository hard to find
(London, United Kingdom)
Rating
[?]

Book Description Springer, Netherlands, 2011. Paperback. Book Condition: New. Language: English . This book usually ship within 10-15 business days and we will endeavor to dispatch orders quicker than this where possible. Brand New Book. Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human insulin in quantities sufficiently large for therapy has been made available by two techniques developed in parallel during the late 1970s. These involve either (i) formulation in E. coli bacteria suitably encoded by DNA recombinant methods of the A- and B-chains of human insulin followed by a chain combination reaction ( biosynthetic human insulin) or (ii) enzymatic conversion (transpeptidation) of porcine insulin brought to react with a threonine ester by porcine trypsin in a mixture of water and organic solvents, yielding human insulin ( semi-synthetic human insulin). This book includes the first clinical-pharmacological studies of each of the highly purified semi-synthetic human insulin preparations: Actrapid (R) HM; Monotard (R) HM; Protaphane (R) HM; Actraphane (R) HM; and Ultratard (R) HM (Novo Industri A/S, Copenhagen). The preliminary studies established their safety and efficacy relative to their porcine and bovine counterparts emphasising the relevance of species and formulation on the pharmacokinetics and biological responses to insulin. Additional investigations with human insulin demonstrated the influence of insulin concentration, site of administration, the addition of aprotinin to insulin and the mixing of short- and intermediate-acting formulations on insulin bioavailability . Examination of the within and between subject day-to-day variation in absorption and the effect of subcutaneous insulin also demonstrates the dominating influence of insulin responsiveness. Softcover reprint of the original 1st ed. 1986. Bookseller Inventory # LIE9789401083478

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 101.83
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

5.

D.R. OWENS
Published by Springer (2011)
ISBN 10: 9401083479 ISBN 13: 9789401083478
New Paperback Quantity Available: 1
Seller:
Herb Tandree Philosophy Books
(Stroud, GLOS, United Kingdom)
Rating
[?]

Book Description Springer, 2011. Paperback. Book Condition: NEW. 9789401083478 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. For all enquiries, please contact Herb Tandree Philosophy Books directly - customer service is our primary goal. Bookseller Inventory # HTANDREE0432784

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 96.07
Convert Currency

Add to Basket

Shipping: US$ 10.66
From United Kingdom to U.S.A.
Destination, Rates & Speeds

6.

D. R. Owens
Published by Springer (2011)
ISBN 10: 9401083479 ISBN 13: 9789401083478
New Quantity Available: > 20
Print on Demand
Seller:
Pbshop
(Wood Dale, IL, U.S.A.)
Rating
[?]

Book Description Springer, 2011. PAP. Book Condition: New. New Book. Shipped from US within 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Bookseller Inventory # IQ-9789401083478

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 103.75
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds

7.

D. R. Owens
Published by Springer (2011)
ISBN 10: 9401083479 ISBN 13: 9789401083478
New Quantity Available: > 20
Print on Demand
Seller:
Books2Anywhere
(Fairford, GLOS, United Kingdom)
Rating
[?]

Book Description Springer, 2011. PAP. Book Condition: New. New Book. Delivered from our UK warehouse in 3 to 5 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Bookseller Inventory # LQ-9789401083478

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 98.65
Convert Currency

Add to Basket

Shipping: US$ 11.99
From United Kingdom to U.S.A.
Destination, Rates & Speeds

8.

Owens, D.R.
Published by Springer
ISBN 10: 9401083479 ISBN 13: 9789401083478
New Softcover Quantity Available: 1
Seller:
Ohmsoft LLC
(Lake Forest, IL, U.S.A.)
Rating
[?]

Book Description Springer. Book Condition: New. Worldwide shipping. FREE fast shipping inside USA (express 2-day delivery also available). Tracking service included. Ships from United States of America. Bookseller Inventory # 9401083479

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 124.78
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

9.

D.R. Owens
Published by Springer (2013)
ISBN 10: 9401083479 ISBN 13: 9789401083478
New Softcover Quantity Available: 15
Print on Demand
Seller:
Rating
[?]

Book Description Springer, 2013. Book Condition: New. This item is printed on demand for shipment within 3 working days. Bookseller Inventory # LP9789401083478

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 123.06
Convert Currency

Add to Basket

Shipping: US$ 3.51
From Germany to U.S.A.
Destination, Rates & Speeds

10.

D. R. Owens
Published by Springer
ISBN 10: 9401083479 ISBN 13: 9789401083478
New Paperback Quantity Available: > 20
Seller:
BuySomeBooks
(Las Vegas, NV, U.S.A.)
Rating
[?]

Book Description Springer. Paperback. Book Condition: New. 312 pages. Dimensions: 9.2in. x 6.1in. x 0.7in.Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human insulin in quantities sufficiently large for therapy has been made available by two techniques developed in parallel during the late 1970s. These involve either (i) formulation in E. coli bacteria suitably encoded by DNA recombinant methods of the A- and B-chains of human insulin followed by a chain combination reaction (biosynthetic human insulin) or (ii) enzymatic conversion (transpeptidation) of porcine insulin brought to react with a threonine ester by porcine trypsin in a mixture of water and organic solvents, yielding human insulin (semi-synthetic human insulin). This book includes the first clinical-pharmacological studies of each of the highly purified semi-synthetic human insulin preparations: Actrapid HM; Monotard HM; Protaphane HM; Actraphane HM; and Ultratard HM (Novo Industri AS, Copenhagen). The preliminary studies established their safety and efficacy relative to their porcine and bovine counterparts emphasising the relevance of species and formulation on the pharmacokinetics and biological responses to insulin. Additional investigations with human insulin demonstrated the influence of insulin concentration, site of administration, the addition of aprotinin to insulin and the mixing of short- and intermediate-acting formulations on insulin bioavailability. Examination of the within and between subject day-to-day variation in absorption and the effect of subcutaneous insulin also demonstrates the dominating influence of insulin responsiveness. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Bookseller Inventory # 9789401083478

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 131.96
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

There are more copies of this book

View all search results for this book