Aim of this work is to investigate the role played by graphene and its derivates in some relevant manifacturing process like purification and absorbtion.The chemical phisical properties of this innovative product make possible to understand why they are Used in many bio-medical and other fields like biosensors, in water purifing, to remove heavy metals procedure , in diagnostic field but also in extraction , purifying DNA, RNA and other biomolecule, carrier , adiuvant , antibacterial and other biological and industrial use.The large scale production is different from a laboratory scale but the same chemico- phisical properties are used.The classic drug manifacturing production as well as biopharmaceuticals need to verify the presence of Impurity in the raw material and in the finisched drugs for regulatory need and for patient safety.For this reason it is interesting to verify the use in some large scale manifacturing procedure of innovative products like m RNA Vaccine.

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